Pre-eclampsia Aggravated Clinical Trial
Official title:
Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients
Background: The aim of this prospective study was to evaluate the effect of magnesium on the
reversal of rocuronium-induced neuromuscular block by sugammadex.
Methods: Eighty patients, aged 18 to 60 years, American Society of Anesthesiologists I-II,
undergoing elective gynecological surgery were enrolled. Anaesthesia was induced with
propofol and fentanyl and was maintained with 60% nitrous oxide and Oxygen in sevoflurane.
The magnesium group received 50 milligram/kilogram (mg/kg) Magnesium intravenous (iv) as a
bolus and 15 mg/kg/hour by continuous infusion until the completion of surgery. The placebo
group received the equivalent volume of isotonic saline. For intubation, 0.6 mg/kg
rocuronium was administered and 0.1 mg/kg was added when Train of four (TOF) counts reached
1 or more during the procedure. At the end of the surgery at a TOF count of 1, 4 mg/kg
sugammadex iv was administered. Patients were observed until a TOF ratio of 0.9 was
achieved. Patient-controlled analgesia with intravenous morphine was used postoperatively.
Inclusion criteria:
- American Society of Anesthesiologists physical status I or II
- 18-60 years of age
- undergoing elective gynecological surgery
- requiring endotracheal intubation
Exclusion criteria:
- Patients who had body mass index > 35
- gastroesophageal reflux
- a history of allergy
- used medication known to interact with the drugs being used in this trial
- who experienced expected or unexpected difficulty during intubation or ventilation
- had neuromuscular disease
- hepatic or renal insufficiency
- pregnant
- were American Society of Anesthesiologists III or IV
- had a family history of malignant hyperthermia
- detection if low or high control plasma magnesium levels
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05687669 -
Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU
|
Phase 4 |