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Clinical Trial Summary

The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.


Clinical Trial Description

Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt & water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00581633
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Active, not recruiting
Phase N/A
Start date February 2007
Completion date December 2025

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