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Postural Tachycardia Syndrome clinical trials

View clinical trials related to Postural Tachycardia Syndrome.

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NCT ID: NCT06268288 Recruiting - Clinical trials for Autonomic Dysfunction

Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)

Start date: February 14, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if nVNS will decrease autonomic symptom intensity (COMPASS-31 and Child Functional Disability Inventory) in adolescent patients with postural orthostatic tachycardia syndrome (POTS) in comparison to standard recovery STEPS management.

NCT ID: NCT05630040 Active, not recruiting - Clinical trials for Post-COVID-19 Syndrome

VNS for Long-COVID-19

Start date: November 11, 2022
Phase: N/A
Study type: Interventional

The goal of this proposed clinical case series is to evaluate the effect of a non-invasive vagus nerve stimulation paradigm on: 1) Symptom reporting via validated patient reported outcomes, and 2) objective clinical biomarkers of autonomic nervous system function. This will be a placebo controlled, randomized controlled trial with a crossover design built in. This study will aim to recruit 40 people with Long COVID to be a part of this research.

NCT ID: NCT05618067 Not yet recruiting - Clinical trials for Postural Tachycardia Syndrome

The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity

Start date: December 1, 2024
Phase: N/A
Study type: Interventional

This study is being to see if participating in breathing exercise training and practicing this training will help with Postural tachycardia syndrome (POTS). The information may help doctors to learn more about how the different parts of people's brains communicate.

NCT ID: NCT05618054 Recruiting - Clinical trials for Postural Tachycardia Syndrome

Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

Start date: March 6, 2023
Phase: N/A
Study type: Interventional

This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains communicate.

NCT ID: NCT05409651 Active, not recruiting - Clinical trials for Postural Tachycardia Syndrome

Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention.

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The mechanisms underlying POTS are not well understood. Though heterogeneous in nature, patients often present with symptoms that include fatigue, orthostatic lightheadedness and tachycardia, "brain fog", shortness of breath, and sleep disruption. The central mediator that links observations in disease entities similar to POTS is energy use and balance driven by mitochondrial health. Mitochondrial dysfunction (i.e. respiration defects, reactive oxygen species (ROS) generation, and structural abnormalities) are hallmarks of currently defined syndromes that resemble POTS symptomatology. Many patients with POTS have underlying immune system dysfunction, which, when treated, may improve the patient's overall health. Though autoimmunity has been demonstrated in POTS, overall immune dysregulation may be broader and include immune cell exhaustion and persistent inflammatory cytokine responses. Immune dysfunction including cellular exhaustion and persistent inflammation has been linked to mitochondrial function. Therefore, we hypothesize that a unifying feature of POTS results from latent or continued mitochondrial/immune dysfunction which then impacts multi-organ energy imbalance and immune homeostasis. Understanding and targeting mitochondria utilizing established, novel, and directed approaches including time-restricted eating (TRE) will help to unravel common etiologies and help us to better diagnose, manage, and treat POTS.

NCT ID: NCT05107635 Recruiting - Clinical trials for Postural Tachycardia Syndrome

Inappropriate Sinus Tachycardia Registry

Start date: March 1, 2022
Phase:
Study type: Observational [Patient Registry]

The primary objective of this registry is to capture the real-world data on the outcome of AtriCure Isolator® Synergyâ„¢ Surgical Ablation system (or future iterations) when used to ablate cardiac tissue in patients with Inappropriate Sinus Tachycardia (IST) or Postural Tachycardia Syndrome (POTS) using sinus node sparing hybrid ablation procedures. This is an observational, retrospective and prospective, multicenter, open-label patient registry.

NCT ID: NCT05043051 Recruiting - Clinical trials for Postural Tachycardia Syndrome

Autoimmune Basis for Postural Tachycardia Syndrome

Start date: January 14, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS). The investigators further hypothesize that electrical stimulation of the vagus nerve will improve POTS symptoms, autoimmunity and inflammation.

NCT ID: NCT04943276 Not yet recruiting - Clinical trials for Postural Tachycardia Syndrome

A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia Syndrome

Start date: August 1, 2021
Phase: N/A
Study type: Interventional

The investigators hope to learn the feasibility and preliminary efficacy of the Embr device for improving thermal comfort in individuals with POTS and impaired thermoregulation. Feasibility will be assessed via usage of the Embr device and participant feedback. Preliminary efficacy measures will include temperature-related symptoms and temperature- related quality of life in individuals with POTS and impaired thermoregulation.

NCT ID: NCT04632134 Recruiting - Physical Disability Clinical Trials

Long-term Effects of Transcutaneous Vagal Nerve Stimulation on Postural Orthostatic Tachycardia Syndrome (POTS)

VAG-POTS
Start date: November 10, 2019
Phase: N/A
Study type: Interventional

Postural Orthostatic Tachycardia Syndrome (POTS) is characterized by symptoms of chronic orthostatic intolerance such as fatigue, lightheadedness, dizziness, palpitations and by pronounced tachycardia upon standing. The aims of the present research study are to test whether a daily transcutaneous vagal nerve stimulation (tVNS) performed for 14 consecutive days may improve heart rate response and reduce disabling symptoms while standing.

NCT ID: NCT04310644 Recruiting - Clinical trials for Postural Tachycardia Syndrome

Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

ProANS
Start date: September 15, 2019
Phase:
Study type: Observational [Patient Registry]

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.