Postpartum Thyroiditis Clinical Trial
Official title:
Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregancy
At present, attention to thyroid disease during pregnancy is increasing at home and abroad, but there is relatively little concern about postpartum thyroid disease, especially high incidence of postpartum thyroiditis (PPT). This observational study is to investigate the relationship between different levels of thyroid peroxidase antibody (TPOAb) and postpartum thyroiditis (PPT) in early pregnancy (1-12 weeks of pregnancy), and to explore whether PPT can be predicted by different TPOAb levels. According to the TPOAb level in early pregnancy, the postpartum of pregnant women was followed up, PPT was detected early, and intervention was performed according to thyroid dysfunction.
First pregnant women who between the ages of 18 to 35 years old and normal thyroid function
before pregnancy were selected. Recruit 300 pregnant women who early pregnancy (1-12 weeks of
pregnancy) screening TPOAb positive and normal Free triiodothyronine (FT3), normal free
thyroxine (FT4) ,Thyroid Stimulating Hormone (TSH) <4.78mIU / L as the observation group.
They will be divided into low-level group (TPOAb at 34-102 IU/ml), medium-level group (TPOAb
at 103-204 IU/ml), and high-level group (TPOAb>205) according to TPOAb. Recruit 100 pregnant
women who early pregnancy (1-12 weeks of pregnancy) screening TPOAb negative and normal FT3,
normal FT4,TSH <4.78mIU / L as the Control group.
Thyroid function (FT3, FT4, TSH) and TPOAb, thyroglobulin antibody(TgAb) ,thyroid hormone
receptor antibody(TRAb) will be screened in the observation group and the control group at 3
months, 6 months, and 12 months after delivery. If the mother is diagnosed with postpartum
thyroiditis (PPT), continue to screen for thyroid function (FT3, FT4, TSH) and thyroid
antibodies (TPOAb, TRAb, TgAb) 18 months after delivery. The correlation between the early
pregnancy TPOAb level and postpartum thyroiditis was analyzed between the observation group
and the control group and the observation group. It was explored whether the occurrence of
postpartum thyroiditis (PPT) can be predicted according to the TPOAb level in the first
trimester. And targeted maternal effective follow-up and timely intervention to treat PPT
provide important basis.
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