Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery — Algebra  

Postoperative Wound Infection Clinical Trial

Official title: Monocentric Pilot Study of Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery

Status Not yet recruiting

Clinical Trial Summary

Cardiac surgery patients have a high risk to suffer from postoperative infections. Some studies have shown, that humoral and cellular factors are associated with perioperative immunodysfunction and can increase the risk of postoperative infections. Monocytes in the blood and, especially alveolar macrophages are important for an adequate host defence. In studies the investigators have shown that hemodynamic parameters have a significant influence on the probability to develop postoperative infections. The aim of the study is to investigate, whether cardiac surgery patients have an altered immune function after surgery that is predictive for the latter development of subsequent infections and whether they benefit from a goal-directed volume and hemodynamic therapy.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Postoperative Outcome
• Postoperative Wound Infection
• Surgical Wound Infection
• Wound Infection

• NCT number: NCT01184430
• Study type: Interventional
• Source: Charite University, Berlin, Germany
• Contact: Michael Sander, MD
• Phone: +49 30 450 531
• Email: Michael.Sander@charite.de
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 2013
• Completion date: December 2014