Postoperative Vomiting Clinical Trial
Official title:
Postoperative Vomiting in Children: Evaluation of the Addition of Droperidol to Conventional Bi-prophylaxis
The purpose of this study is to evaluate the benefit of addition of droperidol to prophylaxis with ondansetron and dexamethasone in children with high risk of postoperative vomiting (POV). In adults some authors showed that the effectiveness of prophylaxis is correlated to the number of molecules or specific procedures used.
The overall incidence of postoperative vomiting between 25 and 30% for the pediatric population, but it can reach a much higher incidence associated with certain types of surgery, about 80% in some studies like strabismus surgery for example. The identification of patients at high risk of POV is possible through the use of risk score. It is currently only one pediatric validated risk score, but the investigators conducted a multicenter study on this subject, whose results are being analyzed. This should allow us to identify children at high risk of POV. In this targeted population, the prophylaxis should allow a significant reduction in the incidence of POV. In children only one study tried to evaluate the association of ondansetron, dexamethasone and droperidol to prevent postoperative vomiting. However, different doses of the different molecules were combined, the extremely complicated design of this study and important methodological bias do not provide evidence about the superiority of the combination of three anti-emetics compared with two anti-emetics. Our present randomized, double-blind study is designed to compare the effectiveness of Droperidol in combination with a conventional bi-prophylaxis (dexamethasone/ondansetron) to the conventional bi-prophylaxis alone to decrease the occurrence of postoperative vomiting in children at high risk. The combination ondansetron and dexamethasone is frequently assessed as an association to prevent postoperative vomiting also in the adult population and in the pediatric population. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04759079 -
The Effects of Acupuncture Against Postoperative Nausea and Vomit After Laparoscopic Cholecystectomy
|
N/A | |
Active, not recruiting |
NCT03712891 -
Evaluation of Providing Coffee to Patients Postoperatively to Decrease Length of Stay in the PACU
|
N/A | |
Completed |
NCT05618236 -
Sugammadex and Neostigmine in Pediatric Patients
|
||
Completed |
NCT00793663 -
Depth of Hypnosis and Postoperative Nausea and Vomiting During Xenon Anaesthesia
|
Phase 4 | |
Completed |
NCT00965367 -
Postoperative Nausea and Vomiting and Acupuncture/Acupressure
|
Phase 2/Phase 3 | |
Recruiting |
NCT06305221 -
Effect of Opioid-free Analgesia and Anesthesia on the Quality of Postoperative Recovery and Nausea Vomit in Patients Receiving Laparoscopic Sleeve Gastrectomy
|
N/A | |
Terminated |
NCT02765750 -
Postoperative Outcomes After Positive Intraoperative Messages
|
N/A | |
Terminated |
NCT01798316 -
IV Acetaminophen for Postoperative Analgesia
|
Phase 4 | |
Completed |
NCT01116713 -
Effect of Dexamethasone in Postoperative Symptoms After Mastectomy for Breast Cancer
|
Phase 3 | |
Completed |
NCT03141645 -
Comparison of IV Fluid Loading and Ondansetron in Reduction of PONV After LC
|
N/A | |
Not yet recruiting |
NCT06422793 -
The Impact of Nasogastric Tube Gastric Decompression on Postoperative Nausea and Vomiting in Orthognathic Surgery
|
N/A | |
Recruiting |
NCT02495220 -
Efficacy of Dexmedetomidine for Postoperative Analgesia in Infantile Cataract Surgery
|
Phase 2/Phase 3 | |
Completed |
NCT01575600 -
Effect of Intravenous Fluid Therapy on Postoperative Vomiting in Children Undergoing Otorhinolaryngological Surgery
|
Phase 3 | |
Completed |
NCT03933605 -
Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy
|
N/A | |
Completed |
NCT04466579 -
Influence of Monitoring the Depth of General Anesthesia Upon the Incidence of PONV and Emergence Delirium in Children Undergoing Endoscopic Adenoidectomy in General Anesthesia
|
N/A | |
Completed |
NCT03142464 -
Intravenous Fluids After Laparoscopic Cholecystectomy
|
N/A | |
Completed |
NCT04260659 -
Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy
|
Phase 4 | |
Completed |
NCT02744495 -
Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery
|
Phase 3 | |
Completed |
NCT04411069 -
Simplified Algorithm for the Prevention of Postoperative Nausea and Vomiting in an Oncological Hospital
|
Phase 2 | |
Completed |
NCT04747691 -
Assessing Gastric Motility and Distention in Postoperative Gastrointestinal Surgery Using Bedside Gastric Ultrasound: Predicting Risk of Aspiration Pneumonia, Ileus, Return of Bowel Function
|