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NCT03387956 Clinical Trial

Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

Postoperative Nausea Clinical Trial

Official title:
Intravenous Dexamethasone Combined With Intrathecal Atropine to Prevent Morphine-related Nausea and Vomiting After Cesarean Delivery: A Randomized Double-blinded Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03387956
Other study ID # IRB00009916
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 20, 2017
Est. completion date August 10, 2017

Study information
Verified date June 2018
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

Description:

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Recruitment information / eligibility
Status Completed
Enrollment 120
Est. completion date August 10, 2017
Est. primary completion date July 28, 2017
Accepts healthy volunteers No
Gender Female
Age group 20 Years to 40 Years
Eligibility Inclusion Criteria:

- females

- 18-40 years of age

- elective cesarean delivery under bupivacaine spinal anesthesia

Exclusion Criteria:

- renal disease

- preeclampsia

- liver disease

- cardiac disease

- Coagulopathy

- chronic cough

- nausea

- vomiting

- patient refusal

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Intrathecal atropine
100ug intrathecal atropine will be injected with spinal anesthesia
• dexamethasone
intravenous 8 mg dexamethasone (2ml).

Locations
Country Name City State
Egypt Emad Zarief Kamel Said Assiut

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary postoperative nausea Monitoring scale of nausea and vomiting 24 hours
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