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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05824260
Other study ID # PI2022_843_0099
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 23, 2022
Est. completion date July 2023

Study information

Verified date March 2023
Source Centre Hospitalier Universitaire, Amiens
Contact Stéphane Bar, MD
Phone 03 22 08 79 06
Email bar.stephane@chu-amiens.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Post-operative morbidity and mortality is related to many factors related to the patient's condition, the intra-operative period and the optimisation of intra-operative haemodynamic and respiratory parameters. Many studies have looked at the determinants and factors that increase postoperative complications. However, these have been randomised studies looking at one parameter in particular. This analysis would be the first to investigate the determinants of postoperative complications in a large population of patients undergoing major non-cardiac surgery. This is a post-hoc analysis of patients included in the OPHIQUE study, whose main objective was to evaluate intraoperative haemodynamic management guided by a marker of tissue hypoperfusion (the respiratory quotient).


Recruitment information / eligibility

Status Recruiting
Enrollment 350
Est. completion date July 2023
Est. primary completion date October 21, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Abdominal, orthopaedic or vascular surgery under general anaesthesia and with an estimated duration of surgery > 2 hours - Adult patients (age = 18 years) - ASA score = II - Patient with at least two of the following comorbidities: age > 50 years, high blood pressure (HTA), heart failure, ECG abnormality, smoking, stroke, transient ischemic attack (TIA), peripheral arterial disease (PAD), insulin-dependent or non-insulin-dependent diabetes mellitus (NIDDM), ascites, chronic renal failure (CRF) - Signature of the consent form - Affiliation to a social security scheme Exclusion Criteria: - Severe untreated or unbalanced hypertension - Preoperative renal failure on dialysis - Acute heart failure - Acute coronary insufficiency - Vascular surgery with renal plasty - Cardiac surgery - Permanent laparoscopy - Chronic respiratory failure with home oxygen therapy - Acute respiratory distress syndrome with FiO2>60%. - Preoperative shock - Surgery under spinal anaesthesia and epidural only - Refusal to participate by the patient - Pregnant, parturient or breastfeeding women - Patients under guardianship or curators, under court protection or deprived of public rights - The patient already included in another therapeutic trial with an experimental molecule - Emergency surgery - Patients who do not want their personal data to be used in the framework of the research

Study Design


Locations

Country Name City State
France CHU Amiens-Picardie Amiens

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary NUmber of risk factors associated with postoperative morbidity in major non-cardiac surgery 2 years
Primary Number of risk factors associated with postoperative mortality in major non-cardiac surgery 2 years
Secondary Number of risk factors associated with the occurrence of postoperative renal dysfunction. 2 years
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