Postoperative Lung Injury Clinical Trial
The ideal tidal volume (TV) during one-lung ventilation (OLV) remains controversial. High
tidal volumes may increase the incidence of postoperative lung injury after thoracic
surgery. The investigators thus evaluated the influence of low (5 ml/kg) and high (10 ml/kg)
tidal volumes on arterial oxygenation and Intrapulmonary shunt during OLV.
One hundred patients scheduled for thoracic surgery were enrolled. During OLV, patients were
randomly assigned to 30 minutes of ventilation with high TV (10 ml/kg with zero
end-expiratory pressure (ZEEP)) at a rate of 10 breaths/minute or low tidal volume (5 ml/kg
with 5 cm H2O positive end-expiratory pressure (PEEP)) at a rate of 20 breaths/minute.
During the subsequent 30 minutes, each patient received the alternative management. Minute
volume was thus kept constant during each experimental condition. Arterial blood partial
pressures, hemodynamic responses, and ventilatory parameters were recorded. Results are
presented as means ± SDs; P < 0.05 was considered statistically significant.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science