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Postoperative Ileus clinical trials

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NCT ID: NCT01579175 Completed - Postoperative Ileus Clinical Trials

The Effect of Gum Chewing on Postoperative Ileus After Gynecologic Surgery

GumGyn
Start date: January 2010
Phase: Phase 1/Phase 2
Study type: Interventional

The investigators are randomizing patients to receive chewing gum (Extra Sugar Free, Spearment) every 4 hours during waking hours for 15 minutes versus standard postoperative care. The investigators then have them fill out a survey in house and 1 week after their surgery that record time to first flatus, hunger, toleration of clear liquids and food and some information about pain, satisfaction, and quality of life. The investigators contact them via phone and email a maximum of three times in order to collect this information. 30 days postoperatively the investigators also contact them and perform a chart review for any postoperative complications.

NCT ID: NCT01572155 Completed - Postoperative Ileus Clinical Trials

Pilot Study: Anti-inflammatory Effect of Peroperative Stimulation of the Vagus Nerve

Start date: March 2012
Phase: N/A
Study type: Interventional

Hypothesis: Electrical stimulation of the abdominal vagus nerve has an anti-inflammatory effect and represents a new therapeutic approach to shorten postoperative ileus. Aims: In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of peroperative electrical stimulation of the vagus nerve. To this end, the following aims are formulated: 1. to optimize the technique of intra-operative electrical vagus nerve stimulation 2. to show that electrical stimulation of the intra-abdominal vagus nerve reduces the inflammatory response to abdominal surgery 3. to evaluate whether electrical stimulation of the vagus nerve leads to clinical improvement (collect pilot data)

NCT ID: NCT01559662 Completed - Postoperative Ileus Clinical Trials

Effect of Sugared Chewing Gum on Gastrointestinal Recovery After Major Colorectal Surgery

Start date: August 2010
Phase: N/A
Study type: Interventional

The Purpose of this study is to evaluate the effect of gum chewing on recovery of gastrointestinal function in patient undergoing major colorectal surgery. The investigators hypothesize that patients who chew gum after major colorectal surgery will have faster recovery of gastrointestinal function.

NCT ID: NCT01440712 Completed - Postoperative Ileus Clinical Trials

Study of the Effect of Water Soluble Oral Contrast (Gastrografin) on Postoperative Ileus After Colorectal Surgery

Start date: December 2011
Phase: Phase 4
Study type: Interventional

The purpose of this trial is to determine whether the water-soluble contrast (gastrografin) is more effective in the treatment of postoperative ileus than the conventional one.

NCT ID: NCT01367548 Completed - Postoperative Ileus Clinical Trials

Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus

Start date: July 2003
Phase: Phase 2
Study type: Interventional

A double-blind, randomized, parallel-group study designed to evaluate the safety and activity of IV MNTX in the treatment of Post-Operative Ileus (POI) in patients who underwent segmental colectomies via laparotomy.

NCT ID: NCT01130675 Completed - Postoperative Ileus Clinical Trials

Does Coffee Consumption Prevent or Shorten Postoperative Ileus After Colon Resection?

Start date: April 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if consuming an 8 ounce cup of coffee with breakfast and lunch is effective in preventing or reducing postoperative ileus.

NCT ID: NCT00871325 Completed - Postoperative Ileus Clinical Trials

Effect of TU-100 on Gastrointestinal and Colonic Transit in Humans

Start date: June 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to compare the dose related effects of orally administered TU-100, a botanical agent that modulates gastrointestinal nerves, on gastrointestinal motility and colonic transit of solids.

NCT ID: NCT00708201 Completed - Postoperative Ileus Clinical Trials

A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy

Start date: March 2009
Phase: Phase 4
Study type: Interventional

This study is being conducted to determine whether alvimopan can accelerate recovery of gastrointestinal function following radical cystectomy when compared with a placebo. Secondary objectives of the study are: - to evaluate the effect of alvimopan on hospital length of stay - to evaluate the effect of alvimopan on prespecified postoperative ileus (POI)-related morbidities - to evaluate the overall and cardiovascular safety of alvimopan

NCT ID: NCT00617552 Completed - Postoperative Ileus Clinical Trials

Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery

Start date: July 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether TZP-101 is effective in the management of post operative ileus in subjects undergoing major open abdominal surgery (i.e. partial large bowel resection).

NCT ID: NCT00600158 Completed - Postoperative Ileus Clinical Trials

Effects of Intravenous Local Anesthetic on Bowel Function After Colectomy

Start date: April 2005
Phase: Phase 3
Study type: Interventional

Epidural local anesthetics are the gold standard for shortening duration of bowel dysfunction after bowel surgery. Previous studies suggest that their effect may be in part a result of actions of the local anesthetic outside the epidural space. If local anesthetics could be administered intravenously instead, this might be a safer, easier and less expensive approach. Therefore, this trial will compare the effect on bowel function recovery of intravenous local anesthetics with those administered epidurally.