Plasma Proteomics in Patients With Postoperative Delirium

Postoperative Delirium Clinical Trial

Official title:

Serum Biomarkers for Postoperative Delirium Based on Plasma Proteomic Analysis of Elder Patients Undergoing Cardiac Surgery

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05772026
• Other study ID #: XuzhouCH2023
• Status: Not yet recruiting
• Start date: March 20, 2023
• Est. completion date: January 1, 2025

Study information

• Verified date: February 2023
• Source: Xuzhou Central Hospital
• Contact: Yangzi Zhu, Doctor
• Phone: +86 18168779150
• Email: zhuyz[@]188.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.

Description:

Patients undergoing noncardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. Plasma was isolated from peripheral blood for subsequent proteomic analysis. To study the characteristics of proteins on a large scale, including protein expression levels, post-translational modifications, protein-protein interactions, etc., so as to obtain a comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level. Assessment of imbalanced protein expression in peripheral blood using protein profiling may allow us to better understand the pathological changes occurring at the molecular level of POD. Early detection of patients at high risk of POD can optimize perioperative management and promote rapid postoperative recovery.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 200
• Est. completion date: January 1, 2025
• Est. primary completion date: January 1, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

• Age =65 years old, regardless of gender.

• The patient had clear consciousness and no cognitive impairment, and could cooperate with the investigation and follow-up.

• The ASA classification is I-?.

Exclusion Criteria:

• severe neurological or psychiatric disorders.

• drug and alcohol abuse.

• Patients with cognitive impairment caused by various reasons such as neuropsychiatric symptoms.

• Exclusion criteria included incomplete medical records and failure to complete the postoperative follow-up.

Related Conditions & MeSH terms

• Delirium
• Postoperative Delirium

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Xuzhou Central Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Differences of Quantitative Proteomics between POD and non-POD	Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level.	1 day before surgery
Primary	Differences of Quantitative Proteomics between POD and non-POD after surgery	Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level.	2 day after surgery