Plasma Proteomics in Patients With Postoperative Delirium

Status Not yet recruiting

Clinical Trial Summary

Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.

Clinical Trial Description

Patients undergoing noncardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. Plasma was isolated from peripheral blood for subsequent proteomic analysis. To study the characteristics of proteins on a large scale, including protein expression levels, post-translational modifications, protein-protein interactions, etc., so as to obtain a comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level. Assessment of imbalanced protein expression in peripheral blood using protein profiling may allow us to better understand the pathological changes occurring at the molecular level of POD. Early detection of patients at high risk of POD can optimize perioperative management and promote rapid postoperative recovery. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05772026
Study type	Observational
Source	Xuzhou Central Hospital
Contact	Yangzi Zhu, Doctor
Phone	+86 18168779150
Email	zhuyz@188.com
Status	Not yet recruiting
Phase
Start date	March 20, 2023
Completion date	January 1, 2025

View Details

See also
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