Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT04875182
Other study ID # 26.02.2020- 04/VI
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date May 1, 2021
Est. completion date August 30, 2021

Study information

Verified date May 2021
Source Mugla Sitki Koçman University
Contact Gökhan vural
Phone +905067025348
Email gokhan6201@hotmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia


Description:

Patients who are over 65 years of age and scheduled for femur fixation surgery will be included in the study. Blood samples for zonulin and interleukin-8 levels will be taken at the day prior to the surgery. All patients will be evaluated by Delirium Rating Scale (DRS) for delirium development at the postoperative 1., 2. and 3. days. Patients with a DRS score over 14 points will be included in the Group Delirium. And second blood samples for zonulin and interleukin-8 levels will be taken at the time of diagnosis. Postoperative pain scores of the patients will recorded by using a numerical rating scale (NRS).


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 56
Est. completion date August 30, 2021
Est. primary completion date August 27, 2021
Accepts healthy volunteers No
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria: - patients over 65 years with mini mental state score > 21, undergoing femur fixation surgery Exclusion Criteria: - anticholinergic drug use, known epilepsy, Parkinson, Alzheimer's disease, dementia, cognitive function disorder

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
Evaluation of Delirium development
Postoperative pain scores of the patients will recorded by using a numerical rating scale.

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Dr. Gokhan Vural

Outcome

Type Measure Description Time frame Safety issue
Other Postoperative pain The relation between postoperative delirium development and postoperative pain score will be documanted. the scores are; zero; have no pain. 0-4 points: mid pain. 5-7points: mild pain. 8-10 points pain score will be named severe pain scores. and The correlation between them will be analyzed by statistical analysis. At the postoperative 0., 12., 24 hours
Primary preoperative Zonulin The relation between postoperative delirium development and preoperative blood zonulin levels. The correlation between them will be analyzed by statistical analysis. in the preoperative 24. hour
Primary postoperative Zonulin The relation between postoperative delirium development and postoperative blood zonulin levels The correlation between them will be analyzed by statistical analysis. At the postoperative 72. hour
Secondary preoperative Interleukin-8 The relation between postoperative delirium development and preoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. in the preoperative 24. hour
Secondary postoperative Interleukin-8 The relation between postoperative delirium development and postoperative blood interleukin-8 levels. The correlation between them will be analyzed by statistical analysis. At the postoperative 72. hour
See also
  Status Clinical Trial Phase
Completed NCT03606941 - Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery N/A
Recruiting NCT05990790 - The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium Phase 4
Completed NCT03950440 - Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement
Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Completed NCT02585128 - Predictors of Postoperative Delirium After Transcatheter Aortic Valve Implantation N/A
Recruiting NCT02227225 - Factors Affecting the Incidence of Postoperative Delirium in Frail Elderly N/A
Recruiting NCT01934049 - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Phase 4
Terminated NCT00455143 - Cognitive Protection - Dexmedetomidine and Cognitive Reserve Phase 4
Recruiting NCT05010148 - A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain Phase 3
Completed NCT06178835 - EPO for Postop Delirium in Elderly Patients Phase 4
Recruiting NCT05992506 - Electroencephalographic Biomarker to Predict Postoperative Delirium
Recruiting NCT03839784 - Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Completed NCT04154176 - Validation of the Greek Version of the Confusion Assessment Method Diagnostic Algorithm (CAM) and the Nursing Delirium Screening Scale (Nu-DESC) and Their Inter-rater Reliablity
Not yet recruiting NCT06375265 - Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients N/A
Recruiting NCT05572307 - Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Active, not recruiting NCT03629262 - Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery Phase 4
Not yet recruiting NCT05537155 - Buccal Acupuncture for Delirium Treatment in Older Patients Recovering From Orthopedic Surgery N/A
Completed NCT01964274 - Relevance of the Peripheral Cholinesterase-activity on Neurocognitive Dysfunctions in Surgical Patients
Completed NCT01599689 - Pilot and Feasibility Study of a Mirrors Intervention for Reducing Delirium in Older Cardiac Surgical Patients N/A
Active, not recruiting NCT03291626 - Postoperative Delirium: EEG Markers of Sleep and Wakefulness