Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

Postoperative Delirium Clinical Trial

Official title:

Correlation Between Plasma Oxidized Low Density Lipoprotein Levels And Postoperative Delirium

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03968887
• Other study ID #: 2019-092
• Status: Not yet recruiting
• Start date: May 20, 2019
• Est. completion date: September 20, 2019

Study information

• Verified date: May 2019
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: Lina Yu, MD
• Phone: +86 13958033387
• Email: zryulina[@]zju.edu.cn
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Postoperative delirium (POD) refers to an acute neurocognitive disorder that occurs within 1 week after surgery or before discharge. Old age is one of the important risk factors for postoperative delirium. The incidence rate of the elderly is high, and the life span of human beings is increasing. Postoperative delirium has adverse effects on both short-term and long-term outcomes, including mortality, ability to work, and dependence on society.

Low-density lipoprotein (LDL) is a key molecule in the cholesterol transport mechanism and is easily oxidized to oxidized low-density lipoprotein (OxLDL). Oxidized low density lipoproteins are immunogenic and are also cytotoxic to endothelial cells. Some studies have shown that increased oxidative stress is one of the earliest changes in disease, and similar signs can be detected in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), such as protein oxidation and lipids. An increase in the quality of the peroxidation index. For the study of anesthesiology, oxidative stress theory has long been recognized as one of the mechanisms of postoperative delirium. We have a hypothesis that plasma oxidized low-density lipoprotein levels are associated with postoperative delirium and can be used as an early warning marker for disease occurrence.

Based on clinical research data, we conducted a prospective cohort study to explore the correlation between plasma oxidized low-density lipoprotein levels and postoperative sputum, providing clinical prediction and diagnostic value.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 300
• Est. completion date: September 20, 2019
• Est. primary completion date: September 20, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years to 90 Years

Eligibility

Inclusion Criteria:

• Surgical treatment was performed in our hospital under standard anesthesia.

• Patients in orthopedics, urology and general surgery.

Exclusion Criteria:

• Patients with mental illness or taking psychotropic substances before surgery.

• Preoperative dementia or cognitive dysfunction.

• Unable to communicate and cooperate with patients due to coma, language barrier or end-stage disease before surgery.

• ASA greater or equal to 4.

• Patients who have undergone neurosurgery and cardiac vascular surgery.

Related Conditions & MeSH terms

• Delirium
• Postoperative Delirium

Intervention

Other:
• plasma oxidized low-density lipoprotein levels
Detection of plasma oxidized low-density lipoprotein levels

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	plasma oxidized low-density lipoprotein levels	Preoperative plasma oxidized low-density lipoprotein levels	through study completion, an average of 4 months
Primary	plasma oxidized low-density lipoprotein levels	Postoperative plasma oxidized low-density lipoprotein levels	through study completion, an average of 4 months