Optimized Anesthesia to Reduce Incidence of Postoperative Delirium

Postoperative Delirium Clinical Trial

Official title: Optimized Anesthesia to Reduce Incidence of Postoperative Delirium in Elderly Undergoing Elective, Non-cardiac Surgery: a Randomized Controlled Trial (POD-II)

Status Recruiting

Clinical Trial Summary

The purpose of this study is to compare the difference of incidence of postoperative delirium between patients received general anesthesia guided by Bispectral index (BIS) and patients received general anesthesia using standard technique.

Clinical Trial Description

General anesthesia is one of precipitating factor of postoperative delirium which Its mechanism is still unknown. General anesthesia can affect on pattern of electroencephalograph. Previous studies showed that patients received BIS guided anesthesia could wake up faster, earlier extubation and stay in recovery room shorter compared to standard general anesthesia. Optimized level of anesthesia by BIS could reduce cognitive dysfunction in elderly patients and reduce biological marker of brain injury. Therefore, the investigators hypothesized that adjustment of general anesthesia by BIS guided could protect central nervous system and reduce incidence of postoperative delirium. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Delirium
• Postoperative Delirium

• NCT number: NCT02133430
• Study type: Interventional
• Source: Chiang Mai University
• Contact: Dr. Yodying Punjasawadwong, MD
• Phone: +66819928082
• Email: typunja@gmail.com
• Status: Recruiting
• Phase: Phase 2/Phase 3
• Start date: January 2014
• Completion date: April 2015