Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

Postoperative Complications Clinical Trial

Official title:

A Clinical Cohort Study on the Effect of Preserving Left Colonic Artery During Radical Resection of Rectal Cancer on Anastomotic Leakage and Oncology Efficacy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03776370
• Other study ID #: 20181155
• Status: Completed
• Start date: December 1, 2018
• Est. completion date: January 1, 2022

Study information

• Verified date: April 2022
• Source: Third Military Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Description:

The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 200
• Est. completion date: January 1, 2022
• Est. primary completion date: January 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

1. Pathological biopsy confirmed adenocarcinoma of the rectum;

2. Preoperative assessment of tolerance to surgery without major organ dysfunction;

3. Patients must be able to understand and voluntarily sign written informed consent;

4. The surgical method is laparoscopic or robotic anterior rectal cancer resection.

Exclusion Criteria:

1. The patient cannot tolerate the operation;

2. Refusal to sign informed consent;

3. Patients with distant metastasis of rectal cancer;

4. The surgical method was changed to miles or Hartman;

5. Unable to complete the follow - up

Related Conditions & MeSH terms

• Postoperative Complications
• Proteinosis
• Rectal Neoplasms

Intervention

Procedure:
• Preserve the left colonic artery
Preservation of left colonic artery in rectal cancer surgery.
• The left colonic artery is not preserved
The left colonic artery was dissected in rectal cancer surgery.

Locations

Country	Name	City	State
China	zongming,Kang	Chongqing	Chongqing
China	zongming,Kang	Yuzhong	Chongqing

Sponsors (1)

Lead Sponsor	Collaborator
Third Military Medical University

Country where clinical trial is conducted

China, 

References & Publications (2)

Fan YC, Ning FL, Zhang CD, Dai DQ. Preservation versus non-preservation of left colic artery in sigmoid and rectal cancer surgery: A meta-analysis. Int J Surg. 2018 Apr;52:269-277. doi: 10.1016/j.ijsu.2018.02.054. Epub 2018 Mar 1. — View Citation

Sekimoto M, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Doki Y, Mori M. Laparoscopic lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery. Surg Endosc. 2011 Mar;25(3):861-6. doi: 10.1007/s00464-010-1284- — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The incidence of postoperative anastomotic leakage was compared between the two groups.	The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group.	Within 30 days after surgery
Primary	The distant metastasis rates of rectal cancer between the two groups were compared.	The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group.	Two years after surgery
Primary	The local recurrence rates of rectal cancer between the two groups were compared.	The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group.	Two years after surgery
Primary	The five-year survival rates of rectal cancer between the two groups were compared.	The 5-year survival rates of rectal cancer in the intervention group and the control group were compared.	Five years after surgery