Postoperative Analgesia Clinical Trial
Official title:
Comparison Study Between Intrathecal and Intravenous Dexmedetomidine in Lower Limb Surgeries
A prospective, randomized, comparative controlled clinical trial, aiming to compare the use of intrathecal dexmedetomidine by intravenous dexmedetomidine in concern of the first request to analgesia. The secondary end-points were the total postoperative analgesic consumption as well as the VAS.
Seventy patients undergoing lower limb surgeries were included in this study. Using a random
number sequence, patients were enrolled in one of two groups: Group T receiving 5 µg of
dexmedetomidine (Precedex® 100 µg/mL, Hospira, Inc., IL, U.S.A.) combined with 12.5 mg of
0.5% hyperbaric bupivacaine (Marcaine® Spinal Heavy; Astra, Sodertalje, Sweden) and Group V
receiving the same bupivacaine DOSE AND 0.75 microgram/kilogram of body weight
dexmedetomidine intravenously. Dexmedetomidine 100 µg/mL was mixed with preservative-free
normal saline to 10 µg/mL. The 0.5 mL of dilute dexmedetomidine was added to the bupivacaine
in group T. An independent investigator prepared the drug solutions and provided the coded
drug to the anaesthetic administrator before the start of the anaesthesia. The anaesthetic
administrator, patients, outcome assessors, and data analysts were blinded to the allocation.
Spinal Anesthesia Patients were hydrated with 500 mL of 0.9% sodium chloride solution before
anaesthesia. The spinal puncture was performed at L3-4 or L4-5 with a midline approach using
a 25 G Quincke needle in the lateral decubitus position. After confirmation of free flow and
clear cerebrospinal fluid, the drug was administered and the patients were then placed in the
supine neutral position.
Assessment: The primary end-point of this study was the first request to analgesia. The
secondary end-points were the total postoperative analgesic consumption as well as the VAS.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05023850 -
Comparing Thoracolumbar Interfascial Plane Block With Erector Spinae Plane Block
|
N/A | |
| Completed |
NCT06205199 -
Analgesic Effect of Ropivacaine Combined With Hydromorphone for CSEA After Total Knee Arthroplasty
|
N/A | |
| Not yet recruiting |
NCT06062550 -
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
|
Phase 4 | |
| Completed |
NCT03239314 -
Analgesic Effect of Adductor Canal Block With and Without Dexamethasone for Knee Arthroscopy
|
N/A | |
| Completed |
NCT05317572 -
Comparison of Three Different Doses of Intrathecal Morphine for Analgesia After Cesarean Section
|
N/A | |
| Recruiting |
NCT06157359 -
Effect of SNB on the QoR in Patients Undergoing Supratentorial Tumor Resection
|
N/A | |
| Completed |
NCT03258255 -
Analgesic Efficiency of Pudendal Nerve Block Versus Penil Block for Circumsion in Children
|
N/A | |
| Recruiting |
NCT06430112 -
Liposomal Bupivacaine vs Ropivacaine for TAPBs
|
Phase 3 | |
| Recruiting |
NCT06078241 -
Postoperative Analgesia in Patients Undergoing Percutaneous Nephrolithotomy
|
N/A | |
| Completed |
NCT04579302 -
Serratus Anterior Block and Erector Spinae Block in Postoperative Analgesia
|
N/A | |
| Completed |
NCT04111848 -
Magnesium and Ketamine in Postoperative Analgesia
|
Phase 4 | |
| Completed |
NCT03341234 -
Superficial Serratus Plane Block for Modified Radical Mastectomy and Axillary Lymph Node Disection
|
N/A | |
| Recruiting |
NCT03540537 -
A Trial Comparing Quadratus Lumborum Block (QLB) and Paravertebral Block (PVTB) for Postoperative Analgesia in Hepatectomy
|
N/A | |
| Terminated |
NCT02150161 -
Opioid vs. Opioid-free Anesthesia for Hip Arthroscopy
|
Phase 3 | |
| Not yet recruiting |
NCT01589354 -
Effectiveness of Interscalene Brachial Plexus Block and Intra-articular Injection of Ropivacaine for Post-operative Analgesia in Arthroscopic Shoulder Stabilization Surgery
|
N/A | |
| Completed |
NCT05855798 -
Ketamine and Magnesium in Erector Spinae Plane Block
|
Phase 4 | |
| Not yet recruiting |
NCT04845711 -
Ultrasound Guided Erector Spinae Plane Block Versus Quadratus Lumborum Block in Laparoscopic Cholecystectomy
|
N/A | |
| Completed |
NCT03131375 -
Dexmedetomidine Reduces Emergence Delirium in Children Undergoing Tonsillectomy With Propofol Anesthesia
|
Phase 2/Phase 3 | |
| Completed |
NCT03885427 -
Analgo-Sedative Effects Of Oral, Or Nebulized Ketamine In Pre-schoolers Undergoing Elective Surgery.
|
Early Phase 1 | |
| Completed |
NCT04738357 -
A Clinical Study to Evaluate Efficacy and Safety of HSK21542 for Postoperative Analgesia of Subjects Undergoing Elective Laparoscopic Surgery Under General Anesthesia
|
Phase 3 |