Postnatal Growth Disorder Clinical Trial
Official title:
Target Fortification of Breast Milk: The Effect of Different Schedules for Milk Analysis on the Growth and Development of Preterm Infants.
It has been observed that target fortification on different schedules leads to meal to meal
variation. It changes the ratio of protein to energy and the percentage of carbohydrate to
non-protein energy which may, affect growth. In the past, the investigators have analyzed
the outcomes of breast milk composition when target fortification is done with different
analysis schedules. The investigators were able to measure the macronutrient intake for
different milk analysis schedules via a theoretical model and show that the more frequent
schedules reduce the variation of fortified-breast milk, whereas a reduced schedule leads to
a high variation of macronutrients. It was observed that, in all the breast milk samples
measured twice per week, infants achieved on average the recommended macronutrients in line
with current recommendations. Nonetheless, the model only looks at the macronutrient intake
and does not investigates the relationship between macronutrient variation and its effect on
growth.
The aim of the current study is to compare a frequent schedule of measurement of
macronutrient analysis with a reduced schedule of measurement and to study its affect on
growth, protein accretion and metabolic parameter.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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