Postherpetic Neuralgia Clinical Trial
Official title:
Kind and Duration of Possible Changes of the Sensory Profiles After the Topical Application of Capsaicin (8%) in Patients With Peripheral Neuropathic Pain
The treatment of neuropathic pain ist still a challenge. A new promising therapy is the use
of capsaicin on skin.
The investigators first experiences with capsaicin in patients with peripheral nerve injury
showed changes in the sensibility, which achieved its maximal extent after four weeks and
was regressive, but not completely abolished 1,5 months after application.
In this study the investigators hope to specify, how long and in which way exactly this
changes in sensibility appear.
The topical application of a high dosage of capsaicin (8%) is a new promising approach.
There is only little knowledge about the extent and the duration of drug-induced changes of
detection and pain thresholds based on a currently recommended standardized quantitative
sensory testing (QST). The assessment of QST changes would be an important step forward to
understand the way of action as well as the time course of the presumed recovering of the
C-fiber function after topical application of a high concentration capsaicin patch.
10 patients suffering from peripheral neuropathic pain due to peripheral nerve injury and 10
patients suffering from postherpetic neuralgia will be investigated by QST following the
protocol of DFNS (German Research Network on Neuropathic Pain), using both thermal and
mechanical nociceptive as well as non-nociceptive stimuli.
QST will be performed at the following times:
- at baseline
- 2, 4, 6, 8 weeks later, and every two weeks at least until re-occurrence of pain and/or
recovering of the capsaicin-induced worsening of the C-fiber function.
;
Observational Model: Cohort, Time Perspective: Prospective
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