Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00305357
Other study ID # H5612-16138
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 2001
Est. completion date December 2006

Study information

Verified date March 2011
Source University of California, San Francisco
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Evolution of pain and neural injury will be evaluated at 2 years or longer after the onset of AHZ by multiple measures. Assessments at 2 years or longer will be compared to those collected during the first 6 months after HZ in order to test whether or not sensory function and cutaneous innervation continues to normalize beyond 6 months in subjects who recover from HZ without severe PHN.


Description:

Pain, nerve trunk inflammation, and neuronal injury are hallmarks of acute herpes zoster (AHZ). We hypothesize that the development of post-herpetic neuralgia (PHN) strongly depends on two factors: 1) the severity of the initial neural injury and 2) the ability to recover from the initial neural injury. To test this hypothesis, we will prospectively follow 150 patients at high risk for development of PHN. Evolution of pain and neural injury will be evaluated at 2-6 weeks, 6 weeks, 3 months, 6 months and at 2 years or longer after the onset of AHZ by multiple measures. Assessments at 2 years or longer will be compared to those collected during the first 6 months after HZ in order to test whether or not sensory function and cutaneous innervation continues to normalize beyond 6 months in subjects who recover from HZ without severe PHN. Preliminary analysis of study data showed reduced innervation in HZ skin, mirror image skin and distant control skin in the acute phase of HZ that was not specific to the persistence of pain at 3 months. The innervation appeared to recover more fully by 6 months in distant control skin than in mirror-image skin and HZ skin, despite the fact that the subjects were continuing to experience a further reduction in their zoster-associated pain. This suggests that the symptoms of pain and sensory dysfunction are not due to a mere loss in overall innervation density. The proposed subsequent ≥ 2 year study visit and analysis will allow us to directly correlate pain resolution with resolution of sensory and innervation abnormalities.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date December 2006
Est. primary completion date November 2005
Accepts healthy volunteers No
Gender All
Age group 50 Years and older
Eligibility Inclusion Criteria: 1. Males and females aged 50 or older and in stable general health. 2. Able and willing to provide written informed consent. 3. Able to understand and follow the instructions of the investigator, including the pain intensity rating scales. 4. Subjects must have an acute outbreak of cervical, thoracic or lumbosacral HZ with unilateral skin rash and pain; the diagnosis will be based on physical examination and review of available medical records confirming the outbreak. 5. The outbreak of herpes zoster must have occurred less than 6 weeks prior to study entry. 6. PHN pain must be of at least moderate severity, defined as self-report of average pain level of 20 mm on a 100 mm visual analog scale. Exclusion Criteria: 1. The AHZ outbreak is complicated by stroke or myelopathy. 2. Patients with facial or cranial AHZ. 3. Patients with signs of spinal cord or brainstem injury from HZ. 4. Patients who are considered unreliable as to study compliance or adherence to scheduled appointments as determined by the Investigators. 5. Patients, who are undergoing active treatment for cancer, are infected with the Human Immunodeficiency Virus, or are being acutely and intensively immunosuppressed following a transplantation procedure. 6. Bleeding disorders. 7. Patients with known skin pathology. 8. Use of topical steroids, capsaicin, local anesthetics or topical aspirin/NSAID preparations within two weeks of the study sessions. 9. Another pain problem of equal or greater severity than AHZ. 10. Allergy or idiosyncratic reaction to lidocaine or capsaicin. 11. Neurological dysfunction or psychiatric disorder severe enough to interfere with assessment of pain and sensory systems. 12. Has received neuroablative nerve blocks or neurosurgical procedures for AHZ pain prior to entering the study. 13. Patients who are unable to read or speak English. 14. Those, in the opinion of the investigator, who are unlikely to comply with the study protocol or who are unsuitable for any other reason.

Study Design


Locations

Country Name City State
United States UCSF San Francisco California

Sponsors (1)

Lead Sponsor Collaborator
University of California, San Francisco

Country where clinical trial is conducted

United States, 

See also
  Status Clinical Trial Phase
Completed NCT01944150 - Association of Transcutaneous Electrical Nerve Stimulation and Hypnosis N/A
Completed NCT00159666 - Study of Pregabalin Therapy for Pain Relief in Subjects With Post-Herpetic Neuralgia Phase 4
Not yet recruiting NCT03120962 - Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia N/A
Completed NCT02701374 - Efficacy and Safety of TRK-700 in Patient With Post-Herpetic Neuralgia Phase 2
Terminated NCT03094195 - Dose Response Study of EMA401 in Patients With Post-herpetic Neuralgia (PHN) Phase 2
Completed NCT02318719 - DS-5565 Phase III Study for Post-herpetic Neuralgia N/A
Completed NCT01752699 - Methadone in Post-Herpetic Neuralgia Pain Phase 3
Completed NCT01250561 - Reduction of Postherpetic Neuralgia in Herpes Zoster N/A
Completed NCT02607280 - DS-5565 Phase III Study for Renal Impairment in Japanese Subjects Phase 3
Completed NCT01037088 - Effects of Vaporized Marijuana on Neuropathic Pain Phase 1/Phase 2
Completed NCT02633306 - Transcranial Magnetic Stimulation for Facial Pain N/A
Recruiting NCT05593237 - Transcranial Magnetic Stimulation for Chronic Neuropathic Pain N/A
Completed NCT01848730 - Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia Phase 2