Post-ERCP Acute Pancreatitis Clinical Trial
Official title:
Effect of Papillary Epinephrine Spraying for the Prevention of Post-ERCP Pancreatitis in Patients Received Sublingual Nitroglycerin: A Multi-center, Single-blind, Randomized Controlled Trial
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most
common complication with high costs, significant morbidity and even mortality. The major
mechanisms of PEP is the papillary edema which is caused by manipulations during cannulation
or endoscopic treatment. The papillary edema may cause temporary outflow obstruction of
pancreatic juice, and then increase ductal pressure, resulting in the occurrence of
pancreatitis. Nitroglycerin can reduce the Oddis sphincter tension, the internal pressure of
the biliary tract and the pancreatic duct. Therefore, it is widely used in clinical to
prevent and treat pancreatitis. Many studies found nitroglycerin might be effective in
preventing PEP. And topical application of epinephrine on the papilla may reduce papillary
edema by decreasing capillary permeability or by relaxing the sphincter of Oddi. There are
reports that epinephrine sprayed on the papilla may be effective to prevent PEP.
The investigators therefore designed a prospective randomized trial to determine whether
routine using papillary epinephrine spraying in patients received octreotide can reduce
post-ERCP pancreatitis.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04546867 -
Establishing a Sonographic Based Algorithm to Verify Pancreatic Stent Position Placed to Prevent Post-ERCP Pancreatitis Before Endoscopic Removal
|
N/A | |
| Terminated |
NCT02241512 -
IV Ibuprofen for the Prevention of Post-ERCP Pancreatitis
|
Phase 2 | |
| Completed |
NCT00222092 -
Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers
|
Phase 4 | |
| Completed |
NCT05310409 -
PAN-PROMISE to Detect Post-ERCP Pancreatitis Symptoms
|
||
| Not yet recruiting |
NCT06260878 -
Short-term Intravenous Fluids for Prevention of Post-ERCP Pancreatitis
|
Phase 4 | |
| Not yet recruiting |
NCT04770857 -
Evaluation of Post-ERCP Pain as a Predictor for Post-ERCP Pancreatitis
|
||
| Completed |
NCT02641561 -
Lactated Ringers With or Without Rectal Indomethacin to Prevent Post-ERCP Pancreatitis
|
Phase 3 | |
| Active, not recruiting |
NCT04145336 -
7 cm vs. 5 cm Pancreatic Stents for the Prevention of Post-ERCP Pancreatitis in High-risk Patients
|
N/A | |
| Completed |
NCT03629600 -
Trial of Aggressive Hydration Versus Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05664074 -
Rectal Indomethacin vs Intravenous Ketorolac
|
Phase 4 | |
| Completed |
NCT02308891 -
A Prospective Trial of Aggressive Hydration Strategy to Reduce Post-ERCP Pancreatitis
|
N/A | |
| Recruiting |
NCT05336630 -
Study of Forceps Cannulation During ERCP
|
N/A | |
| Recruiting |
NCT05857514 -
Randomized Controlled Trial of Rectal Indomethacin Versus Combined Pancreatic Stent Placement and Rectal Indomethacin for Preventing Post-ERCP Pancreatitis
|
N/A | |
| Recruiting |
NCT05267379 -
An European Multi-centre Cohort Study for Unravelling Pharmacokinetic and Genetic Factors Underlying Post-ERCP Pancreatitis
|
||
| Recruiting |
NCT05947461 -
Prevention of Post-ERCP Pancreatitis by Indomethacin vs Diclofenac
|
N/A | |
| Completed |
NCT03098082 -
Urine Trypsinogen 2 Dipstick for the Early Detection of Post-ERCP Pancreatitis
|
N/A | |
| Recruiting |
NCT02830984 -
ENBD After Endoscopic Sphincterotomy Plus Large-balloon Dilation for Preventing PEP
|
N/A | |
| Recruiting |
NCT02839356 -
Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis
|
Phase 4 | |
| Completed |
NCT01673763 -
Post-ERCP Pancreatitis Prevention by Stent Insertion
|
N/A | |
| Active, not recruiting |
NCT04425993 -
Rectal Indomethacin Versus Rectal Indomethacin and Sublingual Nitrate for PEP Prevention
|
N/A |