Post-ERCP Acute Pancreatitis Clinical Trial
Official title:
Effect of Papillary Epinephrine Spraying for the Prevention of Post-ERCP Pancreatitis in Patients Received Sublingual Nitroglycerin: A Multi-center, Single-blind, Randomized Controlled Trial
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most
common complication with high costs, significant morbidity and even mortality. The major
mechanisms of PEP is the papillary edema which is caused by manipulations during cannulation
or endoscopic treatment. The papillary edema may cause temporary outflow obstruction of
pancreatic juice, and then increase ductal pressure, resulting in the occurrence of
pancreatitis. Nitroglycerin can reduce the Oddis sphincter tension, the internal pressure of
the biliary tract and the pancreatic duct. Therefore, it is widely used in clinical to
prevent and treat pancreatitis. Many studies found nitroglycerin might be effective in
preventing PEP. And topical application of epinephrine on the papilla may reduce papillary
edema by decreasing capillary permeability or by relaxing the sphincter of Oddi. There are
reports that epinephrine sprayed on the papilla may be effective to prevent PEP.
The investigators therefore designed a prospective randomized trial to determine whether
routine using papillary epinephrine spraying in patients received octreotide can reduce
post-ERCP pancreatitis.
n/a
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