Blood Conservation in Cardiac Surgery

Post Cardiac Surgery Clinical Trial

Official title: Blood Conservation in Cardiac Surgery

Status Withdrawn

Clinical Trial Summary

The objective of the study is to examine the safety of two different hemoglobin (Hgb)-based transfusion triggers in patients post cardiac surgery.

Clinical Trial Description

Nearly 20% of blood transfusions in the United States are given to in patients undergoing cardiac surgery. Despite the many blood conservation techniques that are available, safe, and efficacious for patients, many of these operations continue to be associated with significant amounts of blood usage. We believe that transfusion protocols which employ specific guidelines for transfusion can decrease blood product usage and improve outcomes for patients undergoing cardiac surgery. Our goal is to demonstrate that a carefully chosen trigger can achieve better outcomes.

Our hypothesis is that a transfusion trigger of Hgb 7.5 g/dl will lead to decreased utilization of blood transfusions and will have many positive effects on the patients post cardiac surgery in addition to substantial cost savings. We will use an evidence based approach to observe the relative safety of a conservative transfusion trigger (7.5 g/dl) as compared to a more liberal trigger (9.0 g/dl). We will also study the effect of blood conservation on the incidence of transfusion-related complications such as transfusion related lung injury (TRALI) and infectious complications as well as length of hospital stay, cost and ventilator time. ;

Related Conditions & MeSH terms

• Post Cardiac Surgery
• Transfusion Reaction
• Transfusion Reactions

• NCT number: NCT01463345
• Study type: Interventional
• Source: Hackensack University Medical Center
• Status: Withdrawn
• Phase: N/A
• Start date: November 2011
• Completion date: May 2013