Copeptin in Differentiation of Polyuria and Polydipsia

Polyuria Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01056887
• Other study ID #: 17121979
• Secondary ID: 33/07
• Status: Completed
• Phase: N/A
• First received: January 25, 2010
• Last updated: April 22, 2011
• Start date: March 2008
• Est. completion date: November 2010

Study information

• Verified date: November 2010
• Source: University of Wuerzburg
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: The Bavarian State Ministry of the Environment and Public Health
• Study type: Observational

Clinical Trial Summary

The differential diagnosis of patients with polyuria/ polydipsia is often complex, but important for the therapeutic strategy.

Challenging is in particular the clinical differentiation between patients with a partial Diabetes insipidus centralis and patients with primary polydipsia as underlying disease, because both groups are associated with similar urinary osmolalities.

The determination of plasma arginine vasopressin is unusual in this context, since measurement of AVP is not reliably.

C-terminal ProVasopressin (copeptin) is secreted stoichiometrically with AVP from the neurohypophysis, but has a longer half life in the circulation, and is thus easier to measure.

Therefore, the investigators will analyze in that study the diagnostic utility of plasma copeptin in the differential diagnosis of polyuria and polydipsia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: November 2010
• Est. primary completion date: November 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients with polydipsia/ polyuria, with indication for performing a deprivation test

• > 18 years

Exclusion Criteria:

• dDAVP during the last 14d

• pregnancy

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Polydipsia
• Polyuria

Locations

Country	Name	City	State
Germany	Univ Hospital Wuerzburg	Wuerzburg	Bavaria

Sponsors (2)

Lead Sponsor	Collaborator
University of Wuerzburg	Dr. Carson Liu Med Corp.

Country where clinical trial is conducted

Germany,