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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03800056
Other study ID # 2017_36
Secondary ID 2017-A03135-48
Status Recruiting
Phase
First received
Last updated
Start date April 23, 2021
Est. completion date April 2026

Study information

Verified date February 2022
Source University Hospital, Lille
Contact Marie-Christine VANTYGHEM, MD,PhD
Phone 320 44 45 17
Email mc-vantyghem@chru-lille.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinomas (SCCs) and may lead to death. The role of chronic Candida infection in the etiopathogenesis of oral SCC is unclear. Long term use of fluconazole lead to emergence of C. albicans strains with azoles decreased susceptibility. CMC is associated with an impaired Th17 cell response, however, it remains unclear whether decreased serum IL-17 and IL-22 levels are related to a defect in cytokine production or to neutralizing autoantibodies resulting from mutations in the AIRE gene


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date April 2026
Est. primary completion date April 2026
Accepts healthy volunteers No
Gender All
Age group N/A to 85 Years
Eligibility Inclusion Criteria: 1. For both of groups, inclusion criteria are : - children aged 0 to 17 years old with the consent of both parents, and men and women between the ages of 18 and 85. - a reasonable delay of 2 weeks after the resolution of an intercurrent infectious episode is to be observed. - assent of the patient after information adapted to his age and his degree of understanding. - informed, express and written consent of the patient or of each of the holders of parental authority. 2. Inclusion criteria specific to group 1: Patients with a APS type 1 whose molecular diagnosis (mutation of the AIRE gene) has been established in the diagnosis of the disease, regardless of their mycological status (history of mycosis) or the presence of antifungal treatment. 3. Inclusion criteria specific to group 2 : Patients with APS type 2: - with adrenal insufficiency for 50% of them. - a delay of two weeks after stopping antifungal or antibiotic treatment in patients is to be respected. Exclusion Criteria: - impossibility to receive informed information for adults, or impossibility to receive enlightened information for the holders of parental authority if minor subject - inability to participate in the entire study, refusal to sign the consent. - people in an emergency situation. - persons deprived of their liberty. - pregnant or lactating woman (pregnant women will be offered to participate in the study after delivery).

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
France Hop Claude Huriez Chu Lille Lille

Sponsors (1)

Lead Sponsor Collaborator
University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type Measure Description Time frame Safety issue
Primary the frequency of appearance of Candida yeast strains the frequency of appearance of Candida yeast strains found in mycological samples from both urinary and oral patients. Baseline: one session
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