Pathogenesis of Primary Spontaneous Pneumothorax

Pneumothorax Clinical Trial

Official title:

Molecular Pathogenesis of Primary Spontaneous Pneumothorax

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01135004
• Other study ID #: 200912060R
• Status: Recruiting
• Phase: N/A
• First received: May 30, 2010
• Last updated: June 1, 2010
• Start date: March 2010
• Est. completion date: February 2013

Study information

• Verified date: March 2010
• Source: National Taiwan University Hospital
• Contact: Jin-Shing Chen, MD, PhD
• Phone: 886-2-23123456
• Email: chenjs[@]ntu.edu.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients.

Description:

Primary spontaneous pneumothorax most commonly occurs in young, tall, lean males. The estimated recurrence rate is 23-50% after the first episode and increases to 60% after the second pneumothorax. The pathogenesis of this benign disease remains unclear. Generally, rupture of the emphysematous change or blebs in the apex of the lung is considered as the cause of pneumothorax. The main purpose of this study is to investigate the molecular pathogenesis of blebs formation or emphysematous change of the lung in these young, healthy patients. The blebs resected from the pneumothorax patients will be used for RNA and protein levels analyses. The adjacent normal lung tissue will be used as a control for comparison.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: February 2013
• Est. primary completion date: February 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 14 Years to 40 Years

Eligibility

Inclusion Criteria:

• Age between 14 and 40 years

• Spontaneous pneumothorax

• Underwent bullectomy of the lung

Exclusion Criteria:

• With underlying lung disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Pneumothorax

Intervention

Procedure:
• Thoracoscopic bullectomy
Thoracoscopic wedge resection of the diseased lung

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (3)

Lead Sponsor	Collaborator
National Taiwan University Hospital	National Science Council, Taiwan, National Taiwan University Hospital, Yun-Lin Branch

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Ayed AK, Chandrasekaran C, Sukumar M. Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax: clinicopathological correlation. Eur J Cardiothorac Surg. 2006 Feb;29(2):221-5. Epub 2005 Dec 20. — View Citation