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Pneumothorax clinical trials

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NCT ID: NCT03804385 Not yet recruiting - Pneumothorax Clinical Trials

Surgical Management of Primary Spontaneous Pneumothorax

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

the different surgical management in patients with primary pneumothorax 0 Objective 1: Identify risk factors that are predictive of the need for surgical intervention. - Objective 2: Determine the value of management strategies in terms of hospital stay - Objective 3: Assess outcomes and postoperative results including symptom relive ,or recurrence or post-operative complications .

NCT ID: NCT03734471 Not yet recruiting - Pneumothorax Clinical Trials

Reactor Thoracostomy

UNCUT
Start date: January 1, 2019
Phase: Phase 3
Study type: Interventional

Tube thoracostomy is commonly performed in the emergency department for patients suffering from traumatic hemo- or pneumo-thorax. The procedure involves the use of a scalpel incision at the skin followed by blunt dissection through tissue, penetration into the thoracic cavity, dilation of a tract for tube placement, exploration of the thoracic cavity with a gloved finger, and finally insertion of a sterile tube into the intrathoracic space. The procedure is considered extremely painful despite the routine provision of systemic analgesics and local anesthetics. Cadaver and animal studies have demonstrated the use of the Reactor chest tube device, a squeeze-activated thoracostomy trochar with placement of a clear sheath for chest tube insertion, to decrease procedure time, incision size, and blood loss. Case series and observational reports suggest lower rates of procedural complication and failure as well as increased patient satisfaction due to pain reduction.

NCT ID: NCT03537417 Not yet recruiting - Pneumothorax Clinical Trials

Heart Rate Variability in Pneumothorax

Start date: June 1, 2018
Phase:
Study type: Observational

Changes in heart rate variability in anesthetized, ventilated patients undergoing tension pneumothorax for thoracoscopic cervical sympathectomy

NCT ID: NCT03227978 Not yet recruiting - PCL Pleurodesis Clinical Trials

PCL (Poly-ε-caprolactone) Mesh Pleurodesis

Start date: August 1, 2017
Phase: Early Phase 1
Study type: Interventional

Recent advances in thoracoscopic surgery have made it a commonly used technique for treating spontaneous pneumothoraces and preventing recurrence. The goal of surgical treatment is to find the offending bleb, remove it, and do some manipulation to encourage pleural symphysis. Methods of thoracoscopic pleural symphysis have included mechanical abrasion and instillation of chemical irritants. Each method reduces the rate of pneumothorax recurrence to a certain degree, but the recurrence rates after thoracoscopic surgery are widely varied in the literature. Although several articles show significantly lower rates, there are also articles demonstrating that the recurrence rates of pneumothorax after thoracoscopic surgery ranged between 5 and 12%, which are higher than the rates reported after open thoracotomy. It is suggested that a less intense pleural inflammatory reaction is induced by thoracoscopic procedure than by thoracotomy. Besides, post-pleurodesis severe pain and bleeding were encountered frequently. A potential alternative to increase the intensity of pleural inflammation and thereby prevent pneumothorax recurrence is film pleurodesis. Only few studies have been reported where more than one film pleurodesis has been tried, and the mechanism of film pleurodesis remains unclear. Poly-ε-caprolactone (PCL) is a FDA-approved biomaterial with a slow degradation time of approximately 24 months when degraded by hydrolysis only. Recently, some investigators combined PCL with other biomaterials such as chitosan, polyethylene glycol, hyaluronic acid to produce anti-adhesion barrier for clinical applications. However, only few studies report PCL only could provide anti-adhesion effect. In contrast to common complications of postoperative abdominal adhesions, adhesion (or pleurodesis) is an important therapeutic tool to control the incidence of recurrent pneumothorax. We suppose that if a biomaterial induces adhesion following abdominal surgery, perhaps it may be applied to pleurodesis tool for preventing recurrence of spontaneous pneumothorax. We hypothesized that PCL membrane-induced pleurodesis can be achieved intrapleurally.

NCT ID: NCT01013298 Not yet recruiting - Hypoxia Clinical Trials

Video-guided Percutaneous Tracheostomy (PCT): A Feasibility Study

Start date: January 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the feasibility, safety and effectiveness of an endotracheal tube embedded with a mini video-camera as a guiding tool for percutaneous tracheostomy.

NCT ID: NCT01012518 Not yet recruiting - Hypoxia Clinical Trials

Video-guided Percutaneous Tracheostomy (PCT) Versus Conventional PCT: Comparing Safety and Efficacy

Start date: January 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the feasibility, safety, efficacy and ease of performance of a video-assisted PCT (via an endotracheal tube embedded with a mini video-camera) with the standard ("blind") PCT technique.