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Clinical Trial Summary

Pneumococcal meningitis is an infection of the membrane that covers the brain. It is a serious infection which is currently treated with a combination of corticosteroids (dexamethasone) and 3rd generation cephalosporins. Nevertheless, complications associated with meningitis are relatively frequent and severe. Recent animal studies have shown that another antibiotic, daptomycin, can reduce the mortality and long-term effects of pneumococcal meningitis. Daptomycin is widely used worldwide in humans for other diseases, with few side effects. This study aims to evaluate the effect of daptomycin on the proliferation of the bacterial infection, and therefore on inflammation. Daptomycin will be added to the currently recommended treatment with the same dosage used for other diseases. Roughly 130 patients with suspected pneumococcal meningitis admitted to the emergency departments of hospitals throughout France will be asked to participate in this study. The participation period will last approximately 3 months.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT03480191
Study type Interventional
Source Centre Hospitalier Universitaire Dijon
Contact Pascal CHAVANET, MD
Phone 03 80 29 33 05
Email pascal.chavanet@chu-dijon.fr
Status Recruiting
Phase Phase 2
Start date June 7, 2018
Completion date September 2024

See also
  Status Clinical Trial Phase
Terminated NCT01478035 - Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Phase 4
Completed NCT00227214 - Study Evaluating Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar. N/A
Completed NCT00162578 - Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis N/A