Clinical Trials Logo

Clinical Trial Summary

The goal of this study is to compare the microbiologic diagnostic yield of pre-aspiration agitated pleural fluid versus that of conventionally aspirated fluid in pleural infection patients. The main question it aims to answer is, whether fluid agitation helps to increase the microbiological yield.


Clinical Trial Description

In pleural infection, It is suggested that the bacteria being diagnostically targeted, might more likely be residing on the pleural surface with a better blood supply and nutrition rather than being planktonic in the acidic, glucose deficient pleural fluid. The investigators thus hypothesize that an agitation of the pleural fluid prior to sample aspiration would aid in achieving a better cellular representation of the pleural space. This could have the effect of washing bacterial cells off the pleural surface as well as moving sedimented cells in the aspirated sample. This study aims to investigate whether an increase in the microbiological yield for infected pleural fluid could be achieved by a pre-aspiration agitation of the pleural fluid which would have a positive effect on management and eventual patient outcomes. Adult participants with pleural infection will undergo thoracentesis via both the standard and agitated fluid techniques guided by thoracic ultrasound. Microbiological yields will be compared. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05702580
Study type Interventional
Source Alexandria University
Contact Ahmed S Sadaka, PhD
Phone +201005433152
Email ahmad.sadaka@alexmed.edu.eg
Status Recruiting
Phase N/A
Start date December 15, 2022
Completion date August 2023

See also
  Status Clinical Trial Phase
Completed NCT04615286 - Short Versus Long Antibiotic Course for Pleural Infection Management (SLIM Trial) N/A
Recruiting NCT05910112 - Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
Recruiting NCT06141174 - Predictors of Outcome in Patients With Pleural Infection at Sohag University Hospital
Completed NCT03468933 - Fibrinolysis Compared to Thoracoscopy for Pleural Infection Phase 4
Not yet recruiting NCT04301869 - Oral Versus Intravenous Antibiotics for the Treatment of Pleural Space Infection: a Randomized Controlled Pilot Trial N/A
Completed NCT02608814 - Advanced Ultrasound in Pleural Infection N/A
Completed NCT04761133 - Antiseptic Irrigation for Pleural Infection Phase 1
Not yet recruiting NCT05766124 - Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) Phase 2/Phase 3
Not yet recruiting NCT06427538 - Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas N/A
Completed NCT02973139 - Fibrinolysis Compared to Thoracoscopy for Pleural Infection N/A
Recruiting NCT05903417 - Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic N/A
Not yet recruiting NCT06434324 - Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion N/A
Completed NCT04569110 - The Microbiology of Pleural Infection
Completed NCT04350502 - Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections N/A