Pleural Effusion Clinical Trial
Official title:
Evaluation and Outcome of Para-pneumonic Effusion Among Children Attending Assuit University Pediatric Hospital
Pleural effusion is the accumulation of excess fluid in the pleural cavity, which results in disturbance of the equilibrium between vascular hydrostatic and oncotic pressures. The underlying causes of pleural effusion include pleural inflammation or infection, congestive heart failure, lymphatic drainage blockage and malignancy.A parapneumonic effusion is a pleural effusion associated with lung infection. Early in the course of parapneumonic effusion, the pleura becomes inflamed with leakage of cellular elements, protein, and fluid into the pleural space, forming the effusion. Subsequent bacterial invasion results in a frank empyema, the presence of which often requires thoracentesis.
A delay in the diagnosis and initiation of proper therapy for infectious effusions leads to
increases in the complication rate. These delays are more common in patients with coexisting
heart failure or malignancy.In fact, pleural effusion manifestations are alerting signs of
pain, dyspnea, and the signs of respiratory failure due to compression of the lungs.
Other signs include tachypnea, decreased percussion, and decreased respiratory sounds. The
most common cause of pleural effusion in children is parapneumonic effusion or purulent
empyema.
Although the prevalence of pleural effusion is high in children, its mortality rate is low .
According to the studies performed in the United States, parapneumonic effusion is known as
the most common underlying cause of pleural effusion in 50% to 70% of the cases . Congenital
heart diseases include 5-15% of the causes and malignancies are the rare reasons of effusion.
In general, effusions may be transudate or exudate and examination of the pleural fluid is
necessary to differentiate them. Exudate is confirmed by the presence of at least one of the
following criteria; pleural effusion concentration higher than half of the serum protein
level, pleural effusion protein level more than 3 g/dL, pleural effusion lactate
dehydrogenase higher than 200 U, pH lower than 7.2, and glucose lower than 40.
C-reactive protein is an acute phase protein that is synthesized by the liver in response to
various stimuli.The induction of C-reactive protein synthesis in the liver is triggered by
the production of Interleukin-6 and Tumor Necrosis Factor-alpha by local pleural cells.
The pleural fluid C-reactive protein levels are likely to reflect the serum levels because
the presence of C-reactive protein in the pleural fluid may be due to increased diffusion
from the blood as a result of inflamed capillary leakage.
Pleural C-reactive protein has been proposed as a specific biomarker for the differential
diagnosis of pleural effusions and reportedly exhibits higher sensitivity and specificity
than serum C-reacive protein. C-reactive protein can be considered a good candidate due to
its 1000-fold elevation in response to infection and the positive correlation between the
serum and pleural C-reactive protein levels. Pleural fluid C-reactive protein level was
significantly higher in exudates than that in transudative effusion.
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