Pleural Effusion Clinical Trial
Official title:
Effects of the Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by Electrical Impedance Tomography and End-Expiratory Lung Volume
Verified date | July 2022 |
Source | Czech Technical University in Prague |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the procedure by electrical impedance tomography (EIT) and concurrently end-expiratory lung volume (EELV) will be measured in order to describe impact of PE evacuation on aeration and ventilation of the lungs.
Status | Completed |
Enrollment | 19 |
Est. completion date | March 30, 2022 |
Est. primary completion date | March 30, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - mechanical ventilation, presence of pleural effusion, decision of the treating physician to drain it Exclusion Criteria: - impossibility to apply EIT belt or to find suitable save point for drainage when the EIT belt is attached - standard EIT exclusion criteria according to the device manufacturer |
Country | Name | City | State |
---|---|---|---|
Czechia | The Military University Hospital | Prague |
Lead Sponsor | Collaborator |
---|---|
Czech Technical University in Prague | Military University Hospital, Prague |
Czechia,
Alves SH, Amato MB, Terra RM, Vargas FS, Caruso P. Lung reaeration and reventilation after aspiration of pleural effusions. A study using electrical impedance tomography. Ann Am Thorac Soc. 2014 Feb;11(2):186-91. doi: 10.1513/AnnalsATS.201306-142OC. — View Citation
Goligher EC, Leis JA, Fowler RA, Pinto R, Adhikari NK, Ferguson ND. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care. 2011;15(1):R46. doi: 10.1186/cc10009. Epub 2011 Feb 2. Review. — View Citation
Mattison LE, Coppage L, Alderman DF, Herlong JO, Sahn SA. Pleural effusions in the medical ICU: prevalence, causes, and clinical implications. Chest. 1997 Apr;111(4):1018-23. — View Citation
Razazi K, Thille AW, Carteaux G, Beji O, Brun-Buisson C, Brochard L, Mekontso Dessap A. Effects of pleural effusion drainage on oxygenation, respiratory mechanics, and hemodynamics in mechanically ventilated patients. Ann Am Thorac Soc. 2014 Sep;11(7):1018-24. doi: 10.1513/AnnalsATS.201404-152OC. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients | Comparison of EIT results with end-expiratory lung volume measurement during drainage of pleural effusion | 4 hours | |
Secondary | Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients | Change of distribution of ventilation over EIT regions of interest (ROIs) | 4 hours |
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