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NCT00172835 Clinical Trial

Use of Procalcitonin in the Diagnosis of Pleural Effusion

Pleural Effusion Clinical Trial

Official title:
Evaluation of Procalcitonin as a Diagnostic Tool for Patients With Pleural Effusion

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00172835
Other study ID # 9461700208
Secondary ID
Status Recruiting
Phase N/A
First received September 12, 2005
Last updated September 12, 2005
Start date March 2005

Study information
Verified date March 2005
Source National Taiwan University Hospital
Contact Po-Ren Hsueh, MD
Phone 886-2-2356-5363
Email prhsueh@ntumc.org
Is FDA regulated No
Health authority Taiwan: Department of Health
Study type Observational

Clinical Trial Summary

Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Clinical diagnosis of pleural effusion

- Pleural effusion proved by chest sonography

Exclusion Criteria:

- Conditions for which thoracentesis are contraindicated

- Pregnancy

Study Design

Allocation: Random Sample, Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan National Taiwan University Hospital Taipei

Sponsors (1)
Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

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