Use of Procalcitonin in the Diagnosis of Pleural Effusion

Status Recruiting

Clinical Trial Summary

Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections. PCT is the prehormone of calcitonin, which is normally secreted by the C cells of the thyroid in response to hypercalcemia; under these normal conditions, negligible serumPCT concentrations are detected. The mechanism proposed for PCT production after inflammation and its role are still not completely known. It is believed that PCT is produced by the liver and peripheral blood mononuclear cells, modulated by lipopolysaccharides and sepsis-related cytokines. It binds to polysaccharides in pathogens, activating the classical complement pathway. The reported diagnostic accuracy of PCT for the diagnosis of bacterial infections has varied across studies.

Clinical Trial Description

n/a

Study Design

Allocation: Random Sample, Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Pleural Effusion

Clinical Trial Details

NCT number	NCT00172835
Study type	Observational
Source	National Taiwan University Hospital
Contact	Po-Ren Hsueh, MD
Phone	886-2-2356-5363
Email	prhsueh@ntumc.org
Status	Recruiting
Phase	N/A
Start date	March 2005

View Details

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