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Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion

Pleural Effusion Clinical Trial

Official title:
Evaluation of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as a Diagnostic Tool for Patients With Pleural Effusion

Clinical Trial Summary

The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.

Clinical Trial Description

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi. Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products. Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1. Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids. The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia. ;

Study Design

Allocation: Random Sample, Observational Model: Natural History, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00166894
Study type Observational
Source National Taiwan University Hospital
Contact Pan-Chyr Yang, MD, PhD
Phone 886-2-2356-2867
Email pcyang@ha.mc.ntu.edu.tw
Status Recruiting
Phase N/A
Start date May 2005
View Details
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