Platelet-Rich Fibrin Clinical Trial
Official title:
Evaluation of Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Surgery With the Use of E-PRF and H-PRF - a Randomized Controlled Clinical Study
This clinical trial aims to compare the effect of platelet concentrates E-PRF and H-PRF on soft and hard tissue healing in healthy individuals after lower third molar surgery. The main questions it aims to answer are: Do E-PRF and H-PRF reduce complications after third molar surgery? Do E-PRF and H-PRF improve soft tissue healing after third molar surgery? Do E-PRF and H-PRF improve hard tissue healing after third molar surgery? Participants will be divided into 2 study groups and one control group. Third molar surgery will be performed according to standard protocol. In study groups, dentoalveolar defects will be filled with E-PRF and H-PRF which are products of centrifugation of the patient's blood without additives. Soft tissue and hard tissue healing will be compared between the groups.
A Randomized, Three Parallel Arms Clinical Trial. The primary objective is to assess the clinical impact of E-PRF vs H-PRF vs Control on the soft tissue healing and post-op discomfort and complications after mandibular third molar surgery between the three groups during the healing period of 7 days. The secondary objective is to compare bony healing between the three groups over three months using an Orthopantomograph (OPG) X-ray. All subjects from the University of Sarajevo Faculty of Dentistry with Dental Clinical Center. Subjects that are coming for the removal of impacted mandibular third molars and match the inclusion criteria will be told about the research and offered the opportunity to participate. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06420713 -
Horizontal Bone Augmentation of Alveolar Ridge
|
N/A | |
Withdrawn |
NCT03715439 -
Evaluation of Dental Implants Placed in Preserved and Non-preserved Post-extraction Ridges
|
||
Recruiting |
NCT06440655 -
The Efficacy and Safety of Platelet-rich Fibrin and Platelet Rich Plasma in Female Pattern Hair Loss Patients
|
N/A | |
Recruiting |
NCT06190860 -
Platelet Rich Fibrin Treatment for the Alveolar Ridge Preservation in Smokers
|
N/A | |
Completed |
NCT05957705 -
Maxillary Sinus Augmentation With Xenogeneic Bone Graft Associated or Not With Fibrin Rich in Platelets and Leukocytes Produced by Horizontal Centrifugation: A Randomized Clinical Trial.
|
N/A | |
Completed |
NCT05264467 -
Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomosis
|
Phase 2/Phase 3 | |
Not yet recruiting |
NCT06044246 -
Influence of Human Platelet Derivatives on Dental Implant
|
N/A | |
Active, not recruiting |
NCT06200727 -
Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
|
N/A | |
Completed |
NCT05753631 -
Effects of i-PRF on Non-surgical Periodontal Treatment
|
||
Recruiting |
NCT05608356 -
Effect of Injectable Platelet-rich Fibrin on the En Masse Retraction of Maxillary Anterior Teeth
|
N/A | |
Completed |
NCT05866965 -
Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery
|
N/A | |
Completed |
NCT05008068 -
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
|
Phase 1 | |
Recruiting |
NCT05766618 -
The Effect of Multiple Injections of (PRF) on The Rate of Canine Retraction
|
Phase 3 | |
Completed |
NCT05409495 -
Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
|
N/A |