Platelet-Rich Fibrin Clinical Trial
Official title:
The Effect of Titanium- Platelet Rich Fibrin in Periodontal Intrabony Defects: A Randomized Controlled Split-Mouth Clinical Study
Verified date | January 2024 |
Source | Ataturk University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, the possible effect of blood group distribution on the content of blood biomaterial was investigated. 64 volunteers were included in the study. Various parameters were evaluated. As a result, it was concluded that blood group distribution does not affect blood biomaterial content.
Status | Completed |
Enrollment | 20 |
Est. completion date | February 15, 2022 |
Est. primary completion date | February 1, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 60 Years |
Eligibility | Inclusion Criteria: 1)Patients with bilaterally similar periodontal intrabone defects (IBDs) Exclusion Criteria: 1. Who did not show the necessary oral hygiene during the non-surgical periodontal treatment process, 2. history of periodontal therapy in the preceding 1 year, 3. presence of devital tooth, Grade II, or higher mobility of the tooth, and less than 3 bone walls or a defect in the furcation at the site of the bone defect, 4. history of any systemic diseases that can alter the course of the periodontal disease, 5. smokers, 6. use of antibiotics, 7. pregnant/lactating women. |
Country | Name | City | State |
---|---|---|---|
Turkey | Atatürk University Faculty of Dentistry Department of Peirodontology | Erzurum |
Lead Sponsor | Collaborator |
---|---|
Ataturk University |
Turkey,
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* Note: There are 23 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | While examining the radiographic intraosseous defect, the distance between the alveolar bone crest and the base of the defect was taken into account. This distance (IBD) was evaluated using computer aided software. | Radiographic Measurements; Measurements were made on radiographic images in order to evaluate the healing of the patient's bone tissue. | 9 month | |
Other | Also while measuring periodontal bone support (PBS) using radiographic images used Image Tool v.3.0 (UTHSCSA). | Radiographic Measurements; Measurements were made on radiographic images in order to evaluate the healing of the patient's bone tissue. | 9 month | |
Primary | site-specific plaque index (PI) (Silness & Loe) | measurement of plaque accumulated on the tooth surface | 9 month | |
Primary | modified sulcus bleeding index (mSBI) | assessment of bleeding gums | 9 month | |
Primary | probing depth from the gingival margin (PD) | evaluated from the gingival margin to the base of the pocket | 9 month | |
Primary | gingival marginal level (GML) | measured from the apical most end of the stent to the crest of the gingival margin | 9 month | |
Primary | relative attachment level (RAL) | evaluated from the cementoenamel junction to the base of the pocket and gingival marginal level | 9 month | |
Secondary | fibroblast growth factors (FGF-2) | growth factor affecting periodontal regeneration | 12 weeks | |
Secondary | platelet-derived growth factors (PDGF-BB) | growth factor affecting periodontal regeneration | 12 weeks | |
Secondary | Gingival Crevicular Fluid Collection; The gingival crevicular fluid (GCF) sample was collected to biochemically evaluate the patient's periodontal tissue healing. | relative ratio of receptor activator nuclear factor kappa-B (RANKL)/osteoprotegerin (OPG)) | 12 weeks |
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