Plantar Fascia Clinical Trial
Official title:
Perforating Fat Injections for Plantar Fasciosis
The specific aim of this study is to determine whether perforating fat injections to the plantar fascia is a safe method to improve pain, quality of life, and reduce plantar fascia thickness for patients with chronic plantar fasciitis. We will also correlate the intrinsic fat properties of adipose stem cells (ie. growth factors) to the improvement in pain, quality of life, and plantar fascia thickness over time.
Aim 1: Evaluate the safety of perforating fat injection into the plantar fascia in patients
with chronic plantar fasciitis to improve pain, quality of life, and thickness of the fascia.
Rationale: Perforating fat injections have been shown to improve multiple scar and fibrotic
conditions such as burn scar contracture, breast radiation injury, and Dupuytren's
contracture of the hand. (5-7) It is thought that the perforations allow expansion of the
tissues, and filling them with fat allows for a regenerative healing process, rather than an
inflammatory scar healing process.
Hypothesis: Perforating fat injections into the chronically thickened plantar fascia is a
safe method to improve pain, quality of life, and reduce tissue thickness.
Aim 2: Correlate intrinsic fat properties of lipoaspirate to improvement in function and
plantar fascia thickness.
Rationale: Adipose tissue contains adipose derived stem cells. Various growth factors
released from the stem cells may have a local effect on soft tissues (ie. VEGF). (8) These
stem cells are thought to promote regenerative healing, rather than scar formation and may
ultimately improve the thickness of the plantar fascia. (9-12) Hypothesis: Intrinsic fat
properties of lipoaspirate (adipose stem cell characteristics) are closely correlated to the
improvements in quality of life and thickness of the plantar fascia.
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