Placenta Previa Clinical Trial
Official title:
Intramuscular 17-Alpha-Hydroxyprogesterone Caproate for Prevention of Emergent Cesarean Delivery in Symptomatic Pregnant Women With Placenta Previa: A Randomized Controlled Study
Purpose to evaluate the effects of intramuscular 17-Alpha-Hydroxyprogesterone Caproate (17-OHPC) for prevention of Emergent Cesarean Delivery in symptomatic Pregnant Women with Placenta Previa
Most authors report an increased risk of bleeding with advancing gestation among women with
placenta previa.
The American College of Obstetricians and Gynecologists (ACOG) and the Society for
Maternal-Fetal Medicine (SMFM) both recommend the use of 17-OHPC to prevent recurrent
spontaneous preterm birth.
Preterm deliveries account for 75% of perinatal mortality and surviving preterm infants are
at risk for neurological, respiratory, and gastrointestinal complications. So, it is
therefore very important to try to prolong the pregnancy without increasing the risk of
emergent delivery in cases with placenta previa. The authors hypothesized that a
pharmacological strategy like 17-alpha-Hydroxyprogesterone caproate may improve pregnancy
outcomes and may also allow obstetricians to tailor their approach to save delayed scheduled
cesarean section women with a placenta previa.
The aim of this study to evaluate the role of17-alpha-Hydroxyprogesterone caproate in the
prevention of preterm cesarean delivery (CD) in cases with symptomatic placenta previa with
avoids of an emergent CD which affects the maternal outcome and prevents prematurity which
affects the prenatal outcome.
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