Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Pigmented Villonodular Synovitis Clinical Trial

Official title:

Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04955535
• Other study ID #: M201947901
• Status: Completed
• Start date: August 3, 2020
• Est. completion date: December 27, 2020

Study information

• Verified date: June 2021
• Source: Peking University Third Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Description:

This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 27, 2020
• Est. primary completion date: December 27, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

1. Clinical diagnosis of pigmented villonodular synovitis.

2. Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion Criteria:

1. No surgical treatment.

2. There were no pathological specimens during the operation.

3. The age of the patient is less than 18 years old or more than 60 years old.

4. The operation record shows nodular type.

Related Conditions & MeSH terms

• Pigmented Villonodular Synovitis
• Synovitis
• Synovitis, Pigmented Villonodular

Intervention

Procedure:
• Arthroscopic synovectomy
Arthroscopic synovectomy

Locations

Country	Name	City	State
China	Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries, Beijing, China	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University Third Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference of scale score between immunohistochemistry positive group and negative group	Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group	One week after surgery
Primary	Difference of Visual Analog Score for pain between TNF-a immunohistochemistry positive group and negative group	Difference of Visual Analog Score for pain between TNF-a immunohistochemistry positive group and negative group	One week after surgery
Primary	Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group	Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group	One week after surgery
Primary	Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group	Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group	One week after surgery
Primary	Difference of SF-36 score between TNF-a immunohistochemistry positive group and negative group	Difference of SF-36 score between TNF-a immunohistochemistry positive group and negative group	One week after surgery
Primary	Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group	Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group	One week after surgery
Secondary	Correlation between basic demographic characteristics and scale scores	Correlation between age, gender and scale score	One week after surgery