PHYSIOLOGICAL PHENOMENA Clinical Trial
Official title:
Importance of Liver Innervation for the Osmopressor Response in Humans
In patients with autonomic dysfunction water drinking elicits a pressor response mediated by
sympathetic activation. If any, in healthy subjects there is only a slight increase in blood
pressure. However, the sympathetic activation is observable by resting energy expenditure
increases greater than 20%.
The investigators believe that the response to water may be mediated through sympathetic
activation elicited by osmosensitve spinal afferents in the liver. Therefore, the
investigators want to test water in liver transplant patients who have a denervated liver.
Kidney transplant patients serve as control subjects. The investigators hypothesize that the
increase in norepinephrine after water drinking is blunted in liver transplant recipients.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05396027 -
Study of Effectiveness of Audio Guided Deep Breathing on Improving the Quality of Life of Physically Disabled Group
|
N/A |