Physical Function Clinical Trial
Official title:
Role of Vitamin D Status on Physical Function and Falls in Adults of Advanced Age
Projections from NHANES III indicate that approximately 12,000,000 U.S. adults ≥ 60 years of
age have vitamin D insufficiency (serum 25(OH)D < 50 nmol/L). A growing body of evidence
suggests that vitamin D status may be important in biologic processes involved in the
maintenance of physical function. To test the hypothesis that vitamin D insufficiency is
associated with poorer muscle strength and physical performance, we propose to evaluate the
role of vitamin D status (serum 25(OH)D) on physical function and falls in the CHS All Stars
cohort, a population of advanced age. The specific aims are as follows:
Specific Aim 1. To describe the prevalence and correlates of vitamin D insufficiency in
adults of advanced age.
Specific Aim 2. To examine the cross-sectional association between vitamin D status and
muscle strength (leg and grip strength), physical performance (3 m/15 ft walk time, repeated
chair stands, and standing balance), self-reported physical function (mobility, ADL and IADL
disability), and falls.
Specific Aim 3. To examine the longitudinal association between vitamin D status at baseline
and incident disability (mobility, ADL and IADL disability) over 3 years of follow-up.
Research Hypotheses: Low vitamin D status (25(OH)D < 50 nmol/L) will be associated with (a)
lower levels of muscle strength and physical performance; (b) higher levels of self-reported
limitations in physical function and falls; and (c) greater odds of incident disability.
n/a
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