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Clinical Trial Summary

This is a comparative, open label, parallel group, non interventional study aims to assess the effect of Ectoine containing eye drops on stromal haze, pain and epithelial healing after Photorefractive keratectomy (PRK). The patient apply Ectohylo eye drops (Ectoine +Sodium Hyauronate) in the right eye and Polyfresh Extra eye drops (Carboxymethyl cellulose + Sodium Hyauronate ) in the left eye plus the routine post PRK treatment in both eyes. Post operative pain , epithelial healing and corneal densitometry is observed in both eyes.


Clinical Trial Description

Photorefractive keratectomy (PRK) is a commonly used operation for laser vision correction. The main fears of this type of laser vision correction is corneal haze, delayed epithelial healing and postoperative severe pain. Ectoine is a natural compound that has the ability to protect biological membranes from damage and environmental effects. This study assess the use of Ectoine containing eye drops to protect the bare ocular surface and reduce inflammation after PRK that will inturn is expected to affect the post operative corneal haze, pain, and epithelial healing . ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05313425
Study type Observational
Source Tanta University
Contact Mohamed Elkadim, MD
Phone 01004991183
Email mzekadem@gmail.com
Status Recruiting
Phase
Start date January 1, 2022
Completion date October 2022

See also
  Status Clinical Trial Phase
Completed NCT04704518 - Phase IV Study to Evaluate the Efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo After Photorefractive Keratectomy (PRK) Phase 4
Completed NCT04281004 - Processed Amniotic Fluid (PAF) Drops After Photorefractive Keratectomy (PRK) Phase 1/Phase 2
Completed NCT00330798 - A Comparison of Topical Nepafenac to Placebo in Corneal Epithelial Healing Times and Postoperative Pain Relief Phase 4
Recruiting NCT05477875 - Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control Phase 2
Completed NCT05973253 - Evaluation of Efficacy and Safety of Topical 1% Medroxyprogesterone in the Corneal Epithelium Healing After PRK Phase 2/Phase 3
Terminated NCT01381731 - A Double-masked, Randomized, Placebo-controlled,Pilot Study of Diquafosol Tetrasodium in Subjects Following Photorefractive Keratectomy (PRK) Phase 2