Photochemotherapy Reaction Clinical Trial
Official title:
Photodynamic Therapy Against Candida Spp. in Complete Denture Wearers: a Randomized Clinical Trial
Candida albicans is the most prevalent species in denture-related stomatitis (DS). There are several treatment options for this condition, including the use of antifungal agents such as nystatin and miconazole. The side effects and the increasing number of resistant species caused by the use of these drugs encourage the development of alternative therapies. Photodynamic Therapy (PDT) has been used as a promising treatment of stomatitis. In this randomized clinical trial, the effectiveness of PDT was evaluated. Patients in this study were allocated to two groups. One group was treated with nystatin, and the other group was treated with PDT.
Different Candida species, including albicans, tropicalis, and parapsilosis, are present in
the human oral microbiota, gastrointestinal tract and vagina. These species are typically
harmless commensals. Candida albicans, the most prevalent species, may be present in up to
80% of healthy individuals. This species is found with high frequency in dental prostheses
and is thought to be the main pathogen associated with stomatitis in elderly denture
wearers. Biofilms of Candida albicans are usually found in intravenous catheters,
prostheses, and these biofilms promote a high resistance to antifungal drugs. The standard
treatment of stomatitis is topical antifungal agents, including nystatin and miconazole. The
use of topical antifungal agents has caused some problems. Poor responses to these agents
are the result of dilution and fast elimination of the drug because of the action of the
saliva, which reduced the drug's concentration. The drug's toxicity can cause mild and
transient gastrointestinal side effects, such as nausea, vomiting and diarrhea. Alternative
treatments or adjuvant treatments have been used to treat these diseases, such as the use of
probiotic bacteria and photodynamic therapy (PDT) using a non-toxic dye (photosensitizer -
PS) in combination with a source of visible light with a peak wavelength suitable for
absorption by the PS. The photodynamic process rapidly generates reactive oxygen species
(ROS) such as peroxides, hydroxyl radicals, superoxide ions and singlet oxygen. Singlet
oxygen has been implicated as the major causative agent of cellular damage in the
photodynamic process, but it does not cause cellular damage in host tissues. The amount of
ROS formation is the main predictor of yeast killing.
This study aimed to evaluate the effectiveness of photodynamic therapy (PDT) in the
treatment of denture stomatitis in complete denture wearers.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03212729 -
Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study
|
N/A |