Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity

Photoaging Clinical Trial

Official title:

Double Blind Placebo Controlled Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05882084
• Other study ID #: Asta_Skin_01
• Status: Recruiting
• Phase: N/A
• Start date: July 24, 2023
• Est. completion date: December 31, 2023

Study information

• Verified date: July 2023
• Source: Integrative Skin Science and Research
• Contact: Raja Sivamani, MD
• Phone: 916-524-1216
• Email: research[@]integrativeskinresearch.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is a double-blind placebo controlled study to assess whether oral astaxanthin can improve skin hydration, skin elasticity, improve skin pigmentation, and reduce facial redness.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 24
• Est. completion date: December 31, 2023
• Est. primary completion date: September 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 30 Years to 55 Years

Eligibility

Inclusion criteria:

• Females who are 30 to 55 years of age

• Half of the women will have Fitzpatrick skin type 1-3 and the other half of the women will have Fitzpatrick skin type 4-6

Exclusion criteria:

• Individuals with a known allergy to astaxanthin or other carotenoids (such as zeaxanthin, lutein, lycopene).

• Individuals who are unwilling to discontinue carotenoid supplementation for at least 1 month prior to enrollment

• Individuals unwilling to restrict intake of foods like shrimp, salmon, mangos, carrots, and tomatoes during the study.

• New supplementation within 4 weeks with tocopherol

• Individuals who are unwilling to stay consistent with a facial cleansing regimen.

• Those who are unwilling to discontinue topical hydroquinone, retinoid or benzoyl peroxide for 2 weeks prior to enrollment

• Individuals who are pregnant or breastfeeding.

• Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.

• Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years

Related Conditions & MeSH terms

• Photoaging
• Skin Diseases

Intervention

Dietary Supplement:
• Astaxanthin 6 mg daily
Astaxanthin at 6 mg is given for daily ingestion and compared against placebo.
• Placebo
Placebo

Locations

Country	Name	City	State
United States	Integrative Skin Science and Research	Sacramento	California

Sponsors (2)

Lead Sponsor	Collaborator
Integrative Skin Science and Research	AstaReal

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skin Hydration	Skin hydration measured with a non-invasive device, SkinMoistureMeterSC	8 weeks
Primary	Skin elasticity	Skin elasticity measured with a non-invasive device, Skin Elastimeter	8 weeks
Secondary	Facial pigmentation	Facial pigment as measured by BTBP facial imaging analysis	8 weeks
Secondary	Facial redness	Facial pigment as measured by BTBP facial imaging analysis	8 weeks