Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04729335 |
| Other study ID # |
N201805104 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
April 10, 2019 |
| Est. completion date |
December 31, 2020 |
Study information
| Verified date |
January 2021 |
| Source |
Taipei Medical University WanFang Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
Western medicine, as to disease detection, is based on histological pathology and organ
anatomy, therefore biochemistry and medical imageology were developed to determine the
location and mechanism of the sickness. Chinese medicine, in the other way around, follow the
harmony between man and nature, creating four ways of diagnosis, namely looking, listening,
questioning and pulse feeling, which evaluate the physiological homeostasis by the yin-yang
of qi and blood, further judging the energy exchange between individual and the universe.
Description:
Western medicine, as to disease detection, is based on histological pathology and organ
anatomy, therefore biochemistry and medical imageology were developed to determine the
location and mechanism of the sickness. Chinese medicine, in the other way around, follow the
harmony between man and nature, creating four ways of diagnosis, namely looking, listening,
questioning and pulse feeling, which evaluate the physiological homeostasis by the yin-yang
of qi and blood, further judging the energy exchange between individual and the universe.
Pulse sound provides perfect detection of disease in Chinese medicine. Hence we plan to
digitalize the pulse sound for a better interpretation of the sickness. According to past
studies of pulse sound from radial artery, the lower frequency is below 25Hz, which falls
into the detection range of Messener's corpuscles (2-80Hz), which are located intensively in
index and middle fingers. However, radial artery is relative thinner and the pulse sound is
not easy to target by the microphone, not to mention the interference from artery sclerosis.
To this end our research group developed Phonocardiac spectrometry (PCS) to replace the
traditional pulse instrument.
Since heart beats continuously, we hypothesize that each organ is regularly sending the
signal back to heart, which modulate the contraction and beating of heart, reflecting
different state of each organ. Heart is just like the commander of an orchestra band, who can
direct the rhythm and style of the band by the music score and instruments. Once the
instrument is damaged, the commander (heart) also adjusts himself. PCS can easily locate the
pulse sound, and directly detect and analyze the cardiac spectrum. The real-time state in
heart-organ axis can be readily monitored, recorded and investigated by PCS.
Our preliminary analysis focuses on patients with liver and pancreatic cancers. The results
demonstrate the different pattern of cardiac spectrum between patients and normal people,
which can be further sorted by disease types. By applying PCS measurement and the novel
algorithm calculation to various diseases, we aim to build up a novel platform for disease
screening or even diagnosis.
