Phobia Clinical Trial - Biobehavioral Correlates of Acute Phobic Fear

Status Not yet recruiting

Clinical Trial Summary

This study seeks to measure the time course of circulating proinflammatory markers (interleukin-1 beta [IL-1β], interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-α], and C-reactive protein [CRP]) and salivary alpha amylase (sAA) following laboratory fear arousal. Further, this study seeks to implement neurocognitive, physiological, and self-report measures to explore the role of threat sensitivity as a predictor of this response. The broad research question seeks to better understand the relationship between neurocognitive fear and subsequent stress responding elicited by both the immune system (i.e., proinflammatory markers) and autonomic nervous system (i.e., sAA). In light of these aims, the primary outcomes of the current study are the proinflammatory markers (IL-1β, IL-6, TNF-α, CRP), while secondary outcomes consist of sAA, neurocognitive measures (i.e., dot-probe task), physiological correlates (i.e., heart rate, galvanic skin response), and self-report measures.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Phobia

Clinical Trial Details

NCT number	NCT03813823
Study type	Observational
Source	University of Colorado, Boulder
Contact	Alex Kirk, M.A.
Phone	303-210-8106
Email	alex.kirk@colorado.edu
Status	Not yet recruiting
Phase
Start date	February 4, 2019
Completion date	August 1, 2019

View Details

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