Pharmacokinetics Clinical Trial
Official title:
Effect of Continuous Renal Replacement Therapy and Residual Renal Clearance on Cefiderocol Pharmacokinetics in Critically Ill Adult Patients
Verified date | February 2024 |
Source | Hartford Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Continuous renal replacement therapies (CRRT) such as continuous venovenous hemofiltration are used to provide renal support for critically ill patients with acute kidney injury (AKI), particularly patients who are hemodynamically unstable. It is well known that critically ill patients may experience alterations in antibiotic pharmacokinetics, and as a result, dosing modifications are generally required. There is a need to understand how CRRT affect the pharmacokinetics and disposition of drugs. This study is designed to assess the pharmacokinetics of the new broad-spectrum antibiotic, Cefiderocol, in critically ill patient receiving CRRT.
Status | Active, not recruiting |
Enrollment | 16 |
Est. completion date | October 2024 |
Est. primary completion date | October 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 120 Years |
Eligibility | Inclusion Criteria: 1. Age 18 years or older; 2. Receiving CRRT including CVVH, CVVHD, and CVVHDF support. Exclusion Criteria: 1. Females who are pregnant or breast-feeding; 2. History of any moderate or severe hypersensitivity or allergic reaction to any ß-lactam antibiotic (a history of mild rash to a cephalosporin followed by uneventful re-exposure is not a contraindication); 3. A hemoglobin less than 8 gm/dl at baseline; 4. Acute liver injury, defined as aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5 times the upper limit of normal, or AST or ALT > 3 times the upper limit of normal with an associated total bilirubin > 2 times upper limit of normal; 5. Any rapidly-progressing disease or immediately life-threatening illness (defined as imminent death within 48 hours in the opinion of the investigator); 6. Any condition or circumstance that, in the opinion of the investigator, would compromise the safety of the patient or the quality of study data. |
Country | Name | City | State |
---|---|---|---|
United States | Hartford Hospital | Hartford | Connecticut |
Lead Sponsor | Collaborator |
---|---|
Hartford Hospital | Shionogi Inc. |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cefiderocol concentration | The total and free plasma concentration of cefiderocol over time | 8 to 12 hours | |
Primary | Cefiderocol clearance | The Clearance in liters/hour of Cefiderocol from the plasma | 8 to 12 hours | |
Primary | Cefiderocol maximum concentration | The maximum concentration of Cefiderocol from the plasma | 8 to 12 hours |
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