Pharmacokinetics Clinical Trial
Official title:
Avenanthramide and Saponin Bioavailability in Oat Bran
Verified date | August 2020 |
Source | North Carolina Agriculture & Technical State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Avenanthramides and saponins are types of chemical compounds found naturally in oats.
Avenanthramides have anti-oxidant properties, anti-atherosclerotic, anti-inflammation, and
anti-proliferative effects on cancer cells in vitro. Oat saponins, or avenacosides, have the
ability to bind cholesterol, and thus, the ability to lower blood cholesterol.
Oat bran is a known source of these dietary compounds. This study aims to determine the
bioavailability of these compounds to in the urine of participants after ingesting an oat
bran cereal, both before, and after for multiple time points.
Analytical chemistry will be used to determine the bioavailability of the oat compounds at
each time point. This will help to establish a kinetic curve for the metabolism of these
compounds.
Status | Completed |
Enrollment | 13 |
Est. completion date | January 21, 2016 |
Est. primary completion date | January 21, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - BMI 18.5-25 - Have blood and urine biochemical markers in normal range - Have no known allergy to oat relate foods - Be not taking antibiotics for six months - Be not currently taking medication - Be nonsmoking - Have no alcoholic intoxication - Have no extensive exposure to industrial waste Exclusion Criteria: - Individuals with gout - Individuals with heart disease - Individuals with peripheral vascular diseases - Individuals with degenerative liver - Cancer patients - Patients with diabetes - Individuals with GI disorders - Individuals with endocrine disorders |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
North Carolina Agriculture & Technical State University |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 0-2 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 2-4 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 4-6 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 6-9 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 9-12 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 12-24 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 24-32 hours post-dose | |
Primary | Bioavailability of Avenanthramides and Saponins in Urine | Liquid chromatography-tandem mass spectrometry will be utilized to assess the bioavailability of avenanthramides and saponins in urine. | 32-48 hours post-dose |
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