A Preliminary Drug Drug Interaction Study With TA-8995

Pharmacokinetic Interactions Clinical Trial

Official title: A Phase I, Open Label Study to Assess the Effects of TA-8995 on the Pharmacokinetics of Midazolam and Digoxin in Healthy Male Subjects

Status Completed

Clinical Trial Summary

A study in healthy males to look at how multiple doses of TA-8995 affect blood levels and rate of removal of other drugs, using single doses of digoxin and midazolam as examples, to see if there are any potential drug interactions that might affect patients in future studies. The study will examine whether co-administration of TA-8995 affects the pharmacokinetics of digoxin and midazolam measured by area under the curve (AUC).

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Pharmacokinetic Interactions

• NCT number: NCT02124954
• Study type: Interventional
• Source: Xention Ltd
• Status: Completed
• Phase: Phase 1
• Start date: May 2014
• Completion date: July 2014