Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia — PIPDIA  

Pharmacodynamic Interaction Clinical Trial

Official title: Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Target-controlled Infusion Intravenous Anesthesia During the Induction

Status Completed

Clinical Trial Summary

The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).

Clinical Trial Description

64 cases were randomly divided into four groups, In each group, dexmedetomidine target plasma concentration are 0, 0.4, 0.6, 0.8 ng/ml. Dexmedetomidine administered 15 min before target controlled infusion of propofol. The propofol infusion was started to provide a target effect-site concentration of 1.0ug/ml, and increased by 0.2ug/ml until loss of consciousness when the effect-site concentration and target concentration equilibrium. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Pharmacodynamic Interaction

• NCT number: NCT02777619
• Study type: Interventional
• Source: Guangzhou General Hospital of Guangzhou Military Command
• Status: Completed
• Phase: Phase 4
• Start date: January 2016
• Completion date: July 2016