Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group. Total RNA will also be isolated and profiled to asses the degree to which our gene(s) of interest are expressed in the presence or absence of phantom limb pain. Some proteins, such as inflammatory antibodies or the neurotrophin brain-derived neurotrophic factor (BDNF), will also be assessed for their association(s) with phantom limb pain.


Clinical Trial Description

Most patients (90-95%)with major limb amputations experience a phantom limb--the vivid impression that the limb is still present. In many cases, the sensation is painful for reasons that are currently not well understood. A small subset of amputees (<10%) never experience phantom limb pain (PLP), the painful sensation felt in the amputated limb. This difference suggests that there may be a genetic component that precludes some patients from ever experiencing PLP. Understanding the genetic components of PLP may help in predicting which patients will experience PLP and which amputees will respond to the various treatment options available.

In order to understand the genetic aspects and ultimately develop more effective treatment options in the future, patients with and without PLP will be asked to give 30 mls of blood after overnight fasting. These blood samples will be de-identified and sent to the National Institutes of Health (NIH) in Bethesda, Maryland, where all of the genetic analyses will take place. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01462448
Study type Observational
Source Henry M. Jackson Foundation for the Advancement of Military Medicine
Contact
Status Active, not recruiting
Phase
Start date March 2012
Completion date August 2019

See also
  Status Clinical Trial Phase
Recruiting NCT00388752 - Acupuncture for the Treatment of Phantom Limb and Residual Limb Pain After Amputation Phase 1
Completed NCT01462461 - Virtual Integrated Environment in Decreasing Phantom Limb Pain N/A
Completed NCT00667264 - Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain N/A
Terminated NCT00768248 - Naval Medical Center San Diego (NMCSD) - Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain N/A
Recruiting NCT02684201 - Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees N/A
Completed NCT00731614 - Cognitive Behavior Therapy (CBT) and Mirror Training for Phantom Limb Pain N/A
Recruiting NCT00301444 - A Study to Test the Effectiveness of Mirror-Box and Mental Visualization Treatments on Phantom Limb Pain N/A
Completed NCT05247827 - The Effects of Targeted Phantom Motor Execution on Phantom Limb Control N/A
Terminated NCT00427947 - Leg Amputation and Continuous Sciatic Nerve Block Phase 3
Recruiting NCT03592901 - Phantom Limb Experience After Brachial Plexus Anesthesia